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METHODS AND COMPOSITIONS FOR SEQUENCING NUCLEIC ACIDS USING CHARGE

  • US 20120052489A1
  • Filed: 08/18/2011
  • Published: 03/01/2012
  • Est. Priority Date: 08/26/2010
  • Status: Active Grant
First Claim
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1. A method for sequencing nucleic acids comprising, a) incorporating one or more nucleotides into a plurality of nucleic acids in one or more reaction chambers in contact with one or more ion detectors, wherein said nucleotides comprise a 3′

  • -OH blocking group, said blocking group preventing any further nucleotide incorporation and any further extension of the nucleic acids in which the nucleotide is incorporated unless removed, and b) detecting hydrogen ions released upon nucleotide incorporation by said one or more ion detectors.

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