MODULATION OF DRUG RELEASE RATE FROM ELECTROSPUN FIBERS
First Claim
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1. A co-electrospun polymeric fiber comprising;
- (a) a first polymer comprising a first pharmaceutically active agent or biologically active agent, wherein the first pharmaceutically active agent or biologically active agent is capable of release from the first polymer at a first release rate when the first polymer is not co-electrospun; and
(b) a second polymer comprising a second pharmaceutically active agent or biologically active agent, wherein the second pharmaceutically active agent or biologically active agent is capable of release from the second polymer at a second release rate when the second polymer is not co-electrospun,wherein the first release rate is greater than the second release rate,wherein at least one of the first polymer and the second polymer is non-biodegradable, andwherein the first pharmaceutically active agent or biologically active agent and the second pharmaceutically active agent or biologically active agent are released from the co-electrospun polymeric fibers at a combined release rate between the first release rate and the second release rate.
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Abstract
Disclosed are co-electrospun polymeric fibers comprising polymers comprising pharmaceutically active agents and/or biologically active agents and capable of release at a combined release rate. Also disclosed are processes for preparing polymeric fibers capable of release at a combined release rate. Also disclosed are processes of modulating delivery rate of pharmaceutically active agents and/or biologically active agents. Also disclosed are processes of delivering pharmaceutically active agents and/or biologically active agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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Citations
20 Claims
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1. A co-electrospun polymeric fiber comprising;
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(a) a first polymer comprising a first pharmaceutically active agent or biologically active agent, wherein the first pharmaceutically active agent or biologically active agent is capable of release from the first polymer at a first release rate when the first polymer is not co-electrospun; and (b) a second polymer comprising a second pharmaceutically active agent or biologically active agent, wherein the second pharmaceutically active agent or biologically active agent is capable of release from the second polymer at a second release rate when the second polymer is not co-electrospun, wherein the first release rate is greater than the second release rate, wherein at least one of the first polymer and the second polymer is non-biodegradable, and wherein the first pharmaceutically active agent or biologically active agent and the second pharmaceutically active agent or biologically active agent are released from the co-electrospun polymeric fibers at a combined release rate between the first release rate and the second release rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification