METHODS FOR CONTROLLING BLOOD-GLUCOSE LEVELS IN INSULIN-REQUIRING SUBJECTS
First Claim
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1. A method of controlling blood glucose level in a subject receiving an insulin therapy comprising administering to the subject:
- (i) a dipeptidyl peptidase inhibitor (DPPI);
and (ii) a glucagon-like petide-1 (GLP-1) related peptide.
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Abstract
The present invention relates to methods of controlling blood glucose levels in subjects receiving an insulin therapy. The methods include administering to the subject receiving an insulin therapy a dipeptidyl peptidase inhibitor and a GLP-1 related peptide. The present invention relates also to the use of such a combination for treating insulin-requiring diabetes mellitus and conditions related thereto.
42 Citations
26 Claims
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1. A method of controlling blood glucose level in a subject receiving an insulin therapy comprising administering to the subject:
- (i) a dipeptidyl peptidase inhibitor (DPPI);
and (ii) a glucagon-like petide-1 (GLP-1) related peptide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- (i) a dipeptidyl peptidase inhibitor (DPPI);
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15. A method of optimizing therapeutic efficacy for controlling blood glucose level in a subject receiving an insulin therapy comprising, comprising:
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a. establishing a dose of insulin according to insulin therapy guidelines; b. administering a DPPI to the subject; c. reducing the dose of insulin administered to the subject; and d. administering a GLP-related peptide to the subject. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification