USE OF A NEW STIMULATION DESIGN TO TREAT NEUROLOGICAL DISORDER

• US 20120059438A1
• Filed: 08/30/2011
• Published: 03/08/2012
• Est. Priority Date: 08/30/2010
• Status: Active Grant

• Current Assignee: Dirk D.E. Ridder
• Original Assignee: Dirk D.E. Ridder
• Inventors: De Ridder, Dirk
• Granted Patent: US 8,682,441 B2
• Time in Patent Office: Days
• US Class Current: 607/70
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/37 Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/4812 Detecting sleep stages or cycles
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36075 Headache or migraine
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/361 Phantom sensations, e.g. tinnitus
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36196 Frequency modulation
• CPC Class Codes: A61N 1/378 Electrical supply

Abstract

The method and system described herein relate to stimulating nerve tissue using a pulse generator. A stimulus is created that comprises a signal that is produced from a frequency spectrum having a power spectral density per unit of bandwidth proportional to 1/f^β, wherein β is excludes 0. The stimulus is provided from the pulse generator to at least one stimulation lead; and applied to nerve tissue via one or several electrodes.

Claims

1. A method of stimulating nerve tissue of a patient using a pulse generator, the method comprising:

generating, by a pulse generator, a stimulus that comprises a signal that is produced from a frequency spectrum having a power spectral density per unit of bandwidth proportional to 1/f^β

, wherein β

is excludes 0;

providing the stimulus from the pulse generator to at least one stimulation lead; and

applying the stimulus to nerve tissue of the patient via one or several electrodes of the at least one stimulation lead.

2. The method of claim 1, wherein β

=1.

3. The method of claim 1, wherein β

=2.

4. The method of claim 1, wherein the stimulus is combined with at least one pulse stimulus to be repeated in a tonic manner.

5. The method of claim 1, wherein the stimulus is combined with a burst stimulus that comprises a plurality of groups of spike pulses.

6. The method of claim 1, wherein the stimulus is combined with at least one pulse stimulus to be repeated in a tonic manner and with a burst stimulation that comprises a plurality of groups of spike pulses.

7. The method of claim 1, wherein the stimulus is modulated at any a specific frequency, either by selective power increase, envelope modulation or adding more tonic or burst stimuli of this frequency.

8. A method of stimulating nerve tissue of a patient using a pulse generator, the method comprising:

storing, in the pulse generator, one first stimulation parameter that defines a frequency to be used as the lower bound of a frequency spectrum;

storing, in the pulse generator, one second stimulation parameter that defines a frequency to be used as the upper bound of a frequency spectrum;

generating, by pulse generator, a stimulus that comprises a frequency spectrum between the first stimulation parameter and second stimulation parameter, wherein the frequency and power of the frequency spectrum are inversely proportional;

providing the stimulus from the implantable pulse generator to at least one stimulation lead; and

applying the stimulus to nerve tissue of the patient via at least one electrodes of the at least one stimulation lead.

9. The method of claim 8 wherein the stimulus is further defined as having a frequency spectrum of 1/f^β

, wherein β

excludes 0.

10. The method of claim 8, wherein β

=1.

11. The method of claim 8, wherein β

=2.

12. The method of claim 8, wherein the stimulus is combined with at least one stimulation pulse to be repeated in a tonic manner.

13. The method of claim 8, wherein the pink noise stimulus is combined with a burst stimulus that comprises a plurality of groups of spike pulses.

14. A method of stimulating nerve tissue of a patient using a pulse generator, the method comprising:

storing, in the pulse generator, one first stimulation parameter that defines a frequency to be used as the lower bound of a frequency spectrum;

storing, in the pulse generator, one second stimulation parameter that defines a frequency to be used as the upper bound of a frequency spectrum;

storing, in pulse generator, one third stimulation parameter that defines a frequency at which a peak of a pre-determined amplitude is to occur;

generating, by pulse generator, a stimulus that comprises a frequency spectrum between the first stimulation parameter and second stimulation parameter, wherein the power spectral density is inversely proportional to the frequency, wherein a peak of a predetermined amplitude occurs at the frequency defined by the third stimulation parameter;

providing the stimulus from the pulse generator to at least one stimulation lead; and

applying the stimulus to nerve tissue of the patient via one or several electrodes of the at least one stimulation lead.

15. The method of claim 14, wherein the noise stimulus is combined with at least one stimulation pulse to be repeated in a tonic manner and with a burst stimulation that comprises a plurality of groups of spike pulses.

16. The method of claim 14, wherein the peak occurs at a frequency between 0 and 4 Hertz.

17. The method of claim 14, wherein the peak occurs at a frequency between 4 and 7 Hertz.

18. The method of claim 14, wherein the peak occurs at a frequency between 8 and 12 Hertz.

19. The method of claim 14, wherein the peak occurs at a frequency between 12 and 30 Hertz.