ANTIBACTERIAL MEDICAL EQUIPMENT AND METHOD FOR PRODUCING THE SAME

• US 20120064132A1
• Filed: 05/19/2010
• Published: 03/15/2012
• Est. Priority Date: 05/20/2009
• Status: Active Grant

• Current Assignee: KEIO University, Meiji University
• Original Assignee: KEIO University, Meiji University
• Inventors: Aizawa, Mamoru, Ishii, Ken, Hoshikawa, Tomoyuki, Funao, Haruki
• Granted Patent: US 8,877,222 B2
• Time in Patent Office: Days
• US Class Current: 424/400
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/112 Phosphorus-containing compounds, e.g. phosphates, phosphonates
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/02 Inorganic materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/026 Ceramic or ceramic-like structures, e.g. glasses
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

An object of the present invention is to provide an antibacterial medical equipment which has sufficient antibacterial activity in vivo and is excellent in compatibility with living tissues, and also can maintain antibacterial activity over a long period and has high safety.

An antibacterial medical equipment characterized in that inositol phosphate is bonded to a Ca compound of a medical equipment whose surface is at least coated with a layer of the Ca compound, or a medical equipment comprising the Ca compound. The antibacterial medical equipment as described above, wherein silver ions are bonded to the inositol phosphate. A method for producing an antibacterial medical equipment, which comprises bringing a medical equipment whose surface is at least coated with a layer of a Ca compound, or a medical equipment comprising a Ca compound into contact with an aqueous solution of inositol phosphate to obtain an antibacterial medical equipment in which inositol phosphate is bonded to the Ca compound. The method for producing an antibacterial medical equipment, wherein inositol phosphate is bonded to the Ca compound and then the Ca compound is brought into contact with an aqueous solution containing silver ions to obtain an antibacterial medical equipment in which silver ions are bonded to the inositol phosphate.

Claims

1. An antibacterial medical equipment characterized in that inositol phosphate is bonded to a Ca compound of a medical equipment whose surface is at least coated with a layer of the Ca compound, or a medical equipment comprising the Ca compound.

2. The antibacterial medical equipment according to claim 1, wherein silver ions are bonded to the inositol phosphate.

3. The antibacterial medical equipment according to claim 1 or 2, wherein the inositol phosphate is phytic acid.

4. The antibacterial medical equipment according to claim 1, wherein the Ca compound is hydroxyapatite.

5. The antibacterial medical equipment according to claim 1, wherein the antibacterial medical equipment is an antibacterial implant.

6. A method for producing an antibacterial medical equipment, which comprises bringing a medical equipment whose surface is at least coated with a layer of a Ca compound layer, or a medical equipment comprising a Ca compound into contact with aqueous solution of inositol phosphate to obtain an antibacterial medical equipment in which inositol phosphate is bonded to the Ca compound.

7. The method for producing an antibacterial medical equipment according to claim 6, wherein inositol phosphate is bonded to the Ca compound and then the Ca compound is brought into contact with an aqueous solution containing silver ions to obtain an antibacterial medical equipment in which silver ions are bonded to the inositol phosphate.

8. The method for producing an antibacterial medical equipment according to claim 6 or 7, wherein the inositol phosphate is phytic acid.

9. The method for producing an antibacterial medical equipment according to claim 6, wherein the Ca compound is hydroxyapatite.

10. The method for producing an antibacterial medical equipment according to claim 6, wherein the antibacterial medical equipment is an antibacterial implant.