PHENOL CROSSLINK FOR SENSOR MEMBRANE

• US 20120067734A1
• Filed: 05/13/2011
• Published: 03/22/2012
• Est. Priority Date: 05/13/2010
• Status: Active Grant

• Current Assignee: Konamite Limited
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Wang, Yuan, Gifford, Raeanne
• Granted Patent: US 9,700,851 B2
• Time in Patent Office: Days
• US Class Current: 205/188
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: B01D 2323/30 Cross-linking
• CPC Class Codes: B01D 67/0006 by chemical reactions in-situ polymerisation, polycondensation, cross-linking or reaction for manufacturing composite membranes B01D69/125
• CPC Class Codes: B01D 71/72 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of the groups B01D71/46 - B01D71/70 and B01D71/701 - B01D71/702
• CPC Class Codes: C12Q 1/003 Functionalisation
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 27/40 Semi-permeable membranes or partitions

Abstract

Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.

Claims

1. An interference exclusion membrane formed from a phenol crosslinked with one or more allyl-containing compounds.

2. The membrane of claim 1, wherein the one or more allyl-containing compounds is at least one of allylphenol, allylalcohol, allylamine, and allylcarbamide.

3. The membrane of claim 1, wherein the one or more allyl-containing compounds include a single type of compound.

4. The membrane of claim 1, wherein the one or more allyl-containing compounds include two or more types of compounds.

5. An analyte sensor, comprising:

an electrically active electrode surface; and

a membrane formed from a phenol crosslinked with one or more allyl-containing compounds.

6. The analyte sensor of claim 5, wherein the membrane is disposed on the electrode surface.

7. The analyte sensor of claim 6, further comprising an enzyme layer disposed on the membrane.

8. The analyte sensor of claim 5, further comprising an enzyme layer disposed on the electrode surface, wherein the membrane is disposed on the enzyme layer.

9. The analyte sensor of claim 5, wherein the membrane is configured to provide interference exclusion, peroxide response, stability, and/or solvent resistance.

10. A method, comprising:

providing a sensor;

electropolymerizing a phenol with one or more allyl-containing compounds to form a membrane on the sensor.

11. The method of claim 10, wherein the membrane is formed directly on the sensor, and an enzyme layer is further deposited or formed on the membrane.

12. The method of claim 10, further comprising depositing or forming an enzyme layer on the sensor, and wherein the membrane is formed on the enzyme layer.

13. The method of claim 10, wherein electropolymerizing a phenol with one or more allyl-containing compounds is carried out in presence of a buffer having a pH of about 7.0.

14. The method of claim 10, further comprising curing the membrane at room temperature.

15. The method of claim 10, further comprising curing the membrane by applying heat at a temperature from 150-250°

C.