STABILIZED GLUCAGON SOLUTIONS AND USES THEREFOR
First Claim
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1. A composition for treating a glucagon-responsive medical condition, comprising:
- a pharmaceutically-acceptable aqueous solution of glucagon,wherein the solution has a pH of greater than about 9, andwherein the glucagon remains substantially non-aggregated when the solution is stored at a physiological temperature for at least three days.
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Abstract
Stabilized glucagon solutions, methods of storing and using the stabilized glucagon solutions, and drug delivery devices containing the stabilized glucagon solutions. In some embodiments, the glucagon solutions may be alkaline, such as with a pH of at least about 9. The glucagon solutions may be resistant to aggregation of glucagon when the solutions are stored for a prolonged period, such as at least about three days, at room temperature and/or physiological temperature.
20 Citations
20 Claims
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1. A composition for treating a glucagon-responsive medical condition, comprising:
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a pharmaceutically-acceptable aqueous solution of glucagon, wherein the solution has a pH of greater than about 9, and wherein the glucagon remains substantially non-aggregated when the solution is stored at a physiological temperature for at least three days. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating a glucagon-responsive medical condition, comprising:
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providing an aqueous solution of glucagon at a pH of greater than about 9; storing the solution in liquid form for at least three days at a physiological temperature without substantial aggregation of the glucagon; and delivering at least a portion of the solution into a subject after the step of storing. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A drug delivery system, comprising:
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a container holding an aqueous solution of glucagon at a pH of greater than about 9, the glucagon remaining substantially non-aggregated when the solution is stored at a physiological temperature for at least three days; and an outlet through which the solution is configured to be driven from the container for delivery into a subject. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification