TISSUES PATCHES AND RELATED DELIVERY SYSTEMS AND METHODS

• US 20120071988A1
• Filed: 10/10/2011
• Published: 03/22/2012
• Est. Priority Date: 05/05/2003
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Pugsley, Charles H., McBride-Sakal, Marcia
• Granted Patent: US 8,545,482 B2
• Time in Patent Office: Days
• US Class Current: 623/23.72
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/0213 the fluid retention member being a layer of hydrocolloid, gel forming material
• CPC Class Codes: A61F 13/0226 characterised by the support layer
• CPC Class Codes: A61F 13/0253 characterized by the adhesive material
• CPC Class Codes: A61L 15/40 containing ingredients of undetermined constitution or reaction products thereof , e.g. plant or animal extracts
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body

Abstract

Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A system for delivering a tissue implant includes a catheter having an expandable member at a distal end portion, a carrier placed around the expandable member, and the carrier configured to expand from a contracted state to an expanded state and to receive the tissue implant. The tissue implant contacts the lesion of the alimentary tract when the expandable member expands the carrier to the expandable state.

Claims

1-36. -36. (canceled)

37. A system for delivering a tissue implant to a lesion in an alimentary tract of a patient, comprising:

a catheter having an expandable member at a distal end portion; and

a carrier having an outer surface and an inner surface and placed around the expandable member, the carrier configured to expand from a contracted state to an expanded state and to receive the tissue implant,

wherein the tissue implant contacts the lesion of the alimentary tract when the expandable member expands the carrier to the expandable state.

38. A system according to claim 37, further comprising a retractable sleeve surrounding the carrier to protect the carrier during insertion and placement of the catheter, the sleeve configured to retract from around the carrier prior to the expandable member expanding to the expanded state.

39. A system according to claim 37, wherein the carrier is formed of a plurality of sections which are configured to be folded in the contracted state.

40. A system according to claim 39, wherein at least one of the plurality of panels comprises bio-adhesive material.

41. A system according to claim 39, wherein the carrier constitutes a substrate in which the tissue implant is embedded.

42. A system according to claim 39, wherein the tissue implant is placed on the outer surface of the carrier and configured to be folded together with the plurality of sections in the contracted state.

43. A system according to claim 41, wherein the tissue implant is embedded in a substrate to form a tissue patch on the outer surface of the carrier.

44. A system according to claim 43, wherein the substrate is a bio-absorbable gel.

45. A system according to claim 41, wherein the tissue implant is embedded in the substrate in a form of a cellular suspension.

46. A system according to claim 43, wherein the carrier is configured to be peeled away from the tissue patch once the tissue patch is securely placed.

47. A system according to claim 37, wherein the carrier is made of bio-absorbable material which dissolves over a period of time.

48. A system according to claim 37, wherein the tissue implant is an engineered tissue.

49. A method of delivering a tissue implant to a lesion in a patient'"'"'s body, comprising:

providing a catheter having an expandable member at a distal end portion;

disposing a contracted carrier around the expandable member, the carrier configured to expand to an expanded state and containing the tissue implant;

inserting the catheter and the contracted carrier into a lumen containing the lesion;

positioning the carrier and expandable member at the lesion; and

expanding the expandable member so as to expand the carrier to the expanded state to implant the tissue implant into the lesion.

50. A method according to claim 49, further comprising providing a retractable sleeve which surrounds the folded carrier to protect the folded carrier during insertion of the catheter, wherein the retractable sleeve is configured to retract from around the carrier prior to the expandable member expanding to the expanded state.

51. A method according to claim 49, wherein the carrier is formed of a plurality of sections which are configured to be folded in the contracted state.

52. A method according to claim 51, wherein at least a portion of the plurality of sections include bio-adhesive material.

53. A method according to claim 51, wherein the carrier constitutes a substrate in which the tissue implant is embedded.

54. A method according to claim 51, wherein the tissue implant is placed on the outer surface of the carrier and configured to be contracted with the plurality of sections in the contracted state.

55. A method according to claim 54, wherein the tissue implant is embedded in a substrate to form a tissue patch on the outer surface of the carrier.

56. A method according to claim 55, wherein the substrate is a bio-absorbable gel.

57. A method according to claim 53, wherein the tissue implant is embedded in the substrate in a form of a cellular suspension.

58. A method according to claim 49, wherein the carrier is configured to be peeled away from the tissue patch once the tissue patch is securely placed.

59. A method according to claim 49, wherein the carrier is made of bio-absorbable material which dissolves over a period of time.

60. A method according to claim 49, wherein the tissue implant is an engineered tissue.