Method and System for Non-Invasive Assessment of Coronary Artery Disease
First Claim
Patent Images
1. A method for non-invasive assessment of coronary artery disease based on medical image data comprising:
- generating an anatomical model of a coronary artery from medical image data;
estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation in the medical image data; and
simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
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Abstract
A method and system for non-invasive patient-specific assessment of coronary artery disease is disclosed. An anatomical model of a coronary artery is generated from medical image data. A velocity of blood in the coronary artery is estimated based on a spatio-temporal representation of contrast agent propagation in the medical image data. Blood flow is simulated in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
265 Citations
39 Claims
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1. A method for non-invasive assessment of coronary artery disease based on medical image data comprising:
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generating an anatomical model of a coronary artery from medical image data; estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation in the medical image data; and simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 14, 15)
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11. An apparatus for non-invasive assessment of coronary artery disease based on medical image data comprising:
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means for generating an anatomical model of a coronary artery from medical image data; means for estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation in the medical image data; and means for simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition. - View Dependent Claims (12, 13)
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16. A non-transitory computer readable medium encoded with computer executable instructions for non-invasive assessment of coronary artery disease based on medical image data, the computer executable instructions defining steps comprising:
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generating an anatomical model of a coronary artery from medical image data; estimating a velocity of blood in the coronary artery based on a spatio-temporal representation of contrast agent propagation in the medical image data; and simulating blood flow in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition. - View Dependent Claims (17, 18, 19, 20)
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21. A method of non-invasive assessment coronary flow reserve (CFR) using medical image data, comprising:
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receiving a first sequence of medical image data acquired during a resting state and a second sequence of medical image data acquired during hyperemia; generating a first anatomical model of a coronary artery from the first sequence of medical image data and a second anatomical model of the coronary artery from the second sequence of medical image data; estimating a maximum velocity of blood in the coronary artery during the resting state based on a spatio-temporal representation of contrast agent propagation in the first sequence of medical image data and a maximum velocity of blood in the coronary artery during hyperemia based on a spatio-temporal representation of contrast agent propagation in the first sequence of medical image data; mapping the maximum velocity at rest to an average velocity at rest and the maximum velocity at hyperemia to an average velocity at hyperemia; and calculating the coronary flow reserve for the coronary artery based on the average rest velocity and the average hyperemia velocity. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. An apparatus for non-invasive assessment coronary flow reserve (CFR) using medical image data, comprising:
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means for receiving a first sequence of medical image data acquired during a resting state and a second sequence of medical image data acquired during hyperemia; means for generating a first anatomical model of a coronary artery from the first sequence of medical image data and a second anatomical model of the coronary artery from the second sequence of medical image data; means for estimating a maximum velocity of blood in the coronary artery during the resting state based on a spatio-temporal representation of contrast agent propagation in the first sequence of medical image data and a maximum velocity of blood in the coronary artery during hyperemia based on a spatio-temporal representation of contrast agent propagation in the first sequence of medical image data; means for mapping the maximum velocity at rest to an average velocity at rest and the maximum velocity at hyperemia to an average velocity at hyperemia; and means for calculating the coronary flow reserve for the coronary artery based on the average rest velocity and the average hyperemia velocity. - View Dependent Claims (29, 30, 31, 32, 33)
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34. A non-transitory computer readable medium comprising computer executable instructions for performing non-invasive assessment coronary flow reserve (CFR) using medical image data, the computer executable instructions performing steps comprising:
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receiving a first sequence of medical image data acquired during a resting state and a second sequence of medical image data acquired during hyperemia; generating a first anatomical model of a coronary artery from the first sequence of medical image data and a second anatomical model of the coronary artery from the second sequence of medical image data; estimating a maximum velocity of blood in the coronary artery during the resting state based on a spatio-temporal representation of contrast agent propagation in the first sequence of medical image data and a maximum velocity of blood in the coronary artery during hyperemia based on a spatio-temporal representation of contrast agent propagation in the first sequence of medical image data; mapping the maximum velocity at rest to an average velocity at rest and the maximum velocity at hyperemia to an average velocity at hyperemia; and calculating the coronary flow reserve for the coronary artery based on the average rest velocity and the average hyperemia velocity. - View Dependent Claims (35, 36, 37, 38, 39)
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Specification