METHOD FOR DETERMINING TREATMENTS USING PATIENT-SPECIFIC LUNG MODELS AND COMPUTER METHODS
First Claim
1. A method for determining optimised parameters for mechanical ventilation, MV, of a subject, comprising:
- a) obtaining data concerning a three-dimensional image of the subjects respiratory system,b) calculating a specific three-dimensional structural model of the subject'"'"'s lung structure from the image data obtained in step a),c) calculating a specific three-dimensional structural model of the subject'"'"'s airway structure from the image data obtained in step a),d) calculating a patient-specific three-dimensional structural model of the subject'"'"'s lobar structure from the lung model obtained in step b),e) modeling by a computer, the air flow through the airway, using the models of the airway and lobar structure of the subject obtained in steps c) and d) at defined MV parameters;
f) modeling by a computer, the structural behavior of the airway and the interaction with the flow, using the models of the airway and lobar structure of the subject obtained in steps b) and c) at defined MV parameters, andg) determining the MV parameters which lead to a decrease in airway resistance and hence an increase in lobar mass flow for the same driving pressures according to the model of step d), thereby obtaining optimized MV parameters.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention concerns a method for determining optimised parameters for mechanical ventilation, MV, of a subject, comprising: a) obtaining data concerning a three-dimensional image of the subject'"'"'s respiratory system; b) calculating a specific three-dimensional structural model of the subject'"'"'s lung structure from the image data obtained in step a); c) calculating a specific three-dimensional structural model of the subject'"'"'s airway structure from the image data obtained in step a); d) calculating a patient-specific three-dimensional structural model of the subject'"'"'s lobar structure from the lung model obtained in step b); e) modeling by a computer, the air flow through the airway, using the models of the airway and lobar structure of the subject obtained in steps c) and d) at defined MV parameters; f) modeling by a computer, the structural behavior of the airway and the interaction with the flow, using the models of the airway and lobar structure of the subject obtained in steps b) and c) at defined MV parameters; g) determining the MV parameters which lead to a decrease in airway resistance and hence an increase in lobar mass flow for the same driving pressures according to the model of step d), thereby obtaining optimized MV parameters. It also relates to a method for assessing the efficacy of a treatment for a respiratory condition.
-
Citations
19 Claims
-
1. A method for determining optimised parameters for mechanical ventilation, MV, of a subject, comprising:
-
a) obtaining data concerning a three-dimensional image of the subjects respiratory system, b) calculating a specific three-dimensional structural model of the subject'"'"'s lung structure from the image data obtained in step a), c) calculating a specific three-dimensional structural model of the subject'"'"'s airway structure from the image data obtained in step a), d) calculating a patient-specific three-dimensional structural model of the subject'"'"'s lobar structure from the lung model obtained in step b), e) modeling by a computer, the air flow through the airway, using the models of the airway and lobar structure of the subject obtained in steps c) and d) at defined MV parameters; f) modeling by a computer, the structural behavior of the airway and the interaction with the flow, using the models of the airway and lobar structure of the subject obtained in steps b) and c) at defined MV parameters, and g) determining the MV parameters which lead to a decrease in airway resistance and hence an increase in lobar mass flow for the same driving pressures according to the model of step d), thereby obtaining optimized MV parameters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method for assessing the efficacy of a treatment for a respiratory condition in a subject comprising the steps of:
-
a) obtaining data concerning a pre-treatment three-dimensional image of the subject'"'"'s respiratory system, and a post-treatment three-dimensional image of the subject'"'"'s respiratory system, b) calculating a specific three-dimensional structural model of the subject'"'"'s lung structure from each of the pre- and post-treatment image data obtained in step a), c) calculating a specific three-dimensional structural model of the subject'"'"'s airway structure from each of the pre- and post-treatment image data obtained in step a), d) calculating a patient-specific three-dimensional structural model of the subject'"'"'s lobar structure from each of the pre- and post-treatment lung structure models obtained in step b), e) modeling by a computer, the air flow through the airway at pre- and post-treatment states, using the respective pre- and post-treatment models of the airway and lobar structure of the subject obtained in steps c) and d); f) modeling by a computer, the structural behavior of the airway and the interaction with the flow at pre- and post-treatment states, using the respective pre- and post-treatment models of the airway and lobar structure of the subject obtained in steps c) and d); g) comparing the modeled airflow and structural behaviour pre- and post-treatment to determine the efficacy of a treatment, wherein an efficacious treatment is one that decreases the airway resistance, thereby increasing the lobar mass for the same driving pressure, thereby determining the efficacy of the treatment for the respiratory condition. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
-
Specification