Systems and Methods for Using Online Resources to Design a Clinical Study and Recruit Participants

• US 20120072232A1
• Filed: 04/27/2011
• Published: 03/22/2012
• Est. Priority Date: 04/28/2010
• Status: Abandoned Application

• Current Assignee: Interlife Sciences, Ltd.
• Original Assignee: Interlife Sciences, Ltd.
• Inventors: Frankham, Patrick, Renz, Wolfgang, Nimeh, Tony, Hilal, Mounir, Fahim, Rami, Jamal, Maleek
• Application Number:
  US13/095,676
• Publication Number:
  US 20120072232A1
• Time in Patent Office: Days
• US Class Current: 705/2
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

The present application is directed to methods and systems for tapping online resources to design a clinical trial and/or recruit participants for the clinical trial. In one embodiment, a system for using online resources to design a clinical trial and/or recruit participants includes one or more web crawlers. Each of the web crawler may be configured to collect data related to one or more specified topics during a community identification phase. A data engine of the system processes the collected data into filtered, relevant information that identifies communities of individuals suitable for recruitment. A patient discovery module may, in a patient discovery phase, develop or use a survey to further target interested patients for recruitment and collect information for designing a suitable study or trial. The system may, in an assessment and communication phase, design a study which may be self-managed by the recruited patients. The study may provide feedback for refining or modifying any one of the above phases. The study may also aim to address certain issues faced by the recruited patients, such as ensuring compliant use of a drug, elimination of side-effects, and using a modified therapy to improve the effectiveness of a drug, etc.

Claims

1. A method for identifying one or more online communities comprising discussions related to patients use of a predetermined drug, the method comprising:

(a) determining, by a device, a plurality of keywords corresponding to a predetermined drug and use of the predetermined drug;

(b) obtaining, by the device, a list of web sites that have one or more online communities comprising discussions generated from web site users about use of one or more drugs;

(c) crawling, by the device, each web site in the list of web sites to match discussions among users within each web site to the plurality of keywords corresponding to the predetermined drug and use of the predetermined drug; and

(d) identifying, by the device, one or more online communities from the list of web sites that have patient generated discussions corresponding to the predetermined drug and the use of the predetermined drug.

2. The method of claim 1, wherein step (a) further comprises determining a keyword of the plurality of keywords that describes a side-effect of the use of the predetermined drug.

3. The method of claim 1, wherein step (a) further comprises determining a keyword of the plurality of keywords related to compliance in the use of the predetermined drug.

4. The method of claim 1, wherein step (a) further comprises determining a keyword of the plurality of keywords that identifies a diagnosis corresponding to the use of the predetermined drug.

5. The method of claim 1, wherein step (b) further comprises obtaining the list of web sites from a user specified configuration.

6. The method of claim 1, wherein step (b) further comprises obtaining the list of web sites from crawling a plurality of web sites.

7. The method of claim 1, wherein step (c) further comprises matching a portion of each web site having web site user generated discussions to the plurality of keywords.

8. The method of claim 1, wherein step (c) further comprises filtering each web site to those web sites having discussions from patients focused on the predetermined drug.

9. The method of claim 1, wherein step (d) further comprises ranking each of the one or more online communities according to relevance of member generated discussions to the predetermined drug and the use of the predetermined drug.

10. The method of claim 1, further comprises identifying the one or more online communities having a relevance exceeding a predetermined threshold to solicit for survey participation.

11. The method of claim 1, wherein step (d) further comprises ranking each of the one or more online communities according to a side-effect from use of the predetermined drug.

12. A method for providing a survey based on online community discussions relevant to use of a predetermined drug, the method comprising:

(a) identifying, by a device, a plurality of patients who are users at one or more online communities and provided patient generated discussions about one or more sides effects from use of a predetermined drug;

(b) generating, via the device, a survey based on the plurality of patients discussions, generated online at the one or more online communities, on use of the predetermined drug;

(c) communicating, by the device, a solicitation to the plurality of patients to participate in the survey; and

(d) receiving, by the device responsive to the survey, data on the predetermined drug from patients participating in the survey.

13. The method of claim 12, wherein step (a) further comprising crawling a plurality of web sites to identify the one or more online communities comprising web site user generated discussions matching a plurality of keywords corresponding to the predetermined drug and use of the predetermined drug.

14. The method of claim 13, further comprising identifying from the discussions at the one or more online communities web site users who use the predetermined drug and provided relevant discussions on use of the predetermined drug.

15. The method of claim 12, wherein step (a) further comprising identifying the one or more online communities providing most relevant discussions about use of the predetermined drug.

16. The method of claim 12, wherein step (b) further comprises designing, via the device, the survey to target collecting information on a patient'"'"'s side-effect of use of the predetermined drug.

17. The method of claim 12, wherein step (b) further comprises designing, via the device, the survey to target collecting information on a patient'"'"'s compliance to prescribed use of the predetermined drug.

18. The method of claim 12, wherein step (c) further comprises communicating the solicitation via a network to an electronic contact address of the patient.

19. The method of claim 12, wherein step (c) further comprises posting the solicitation via a network to the one or more online communities.

20. The method of claim 12, wherein step (d) further comprises segmenting, the data received from the survey into one of length of use of the predetermined drug, dosage of the predetermined drug or a side-effect from taking the predetermined drug.

21. The method of claim 12, wherein step (d) further comprises segmenting, the data received from the survey into one of gender or age of the patient.

22. The method of claim 12, wherein step (d) further comprises receiving data from the survey identifying a quality of life index of the patient related to use of the predetermined drug.

23. A method for providing for a drug assessment based on information from patients in online communities, the method comprising:

(a) identifying, by a device, patients from an online survey that indicated interest in participating in an assessment of a predetermined drug;

(b) selecting, via the device based on results from the online survey, the plurality of patients with a predetermined diagnosis and a predetermined side-effect;

(c) generating, via the device, a protocol for the assessment of the predetermined drug based on data collected from the online survey;

(d) communicating, by the device, the protocol to the selected plurality of patients participating in the assessment; and

(e) receiving, by the device, from the selected plurality of patients information on compliance to the protocol and symptom relief from the predetermined side-effect.

24. The method of claim 23, wherein the assessment comprises one of a clinical trial, a compliance program or an adherence program.

25. The method of claim 23, wherein step (a) further comprise identifying the patients from the online survey that are likely to discontinue using the predetermined drug due to one or more side-effects.

26. The method of claim 23, wherein step (a) further comprise identifying the patients from the online survey that exceed a predetermined threshold of risk to discontinue using the predetermined drug due to one or more side-effects.

27. The method of claim 23, wherein step (a) further comprises communicating via a network a request to patients of the one or more online communities to participate in the trial study.

28. The method of claim 23, wherein step (b) further comprises querying, by the device, a database having data collected via the online survey from the plurality of patients from a plurality of online communities.

29. The method of claim 23, wherein step (b) further comprises selecting the plurality of patients who have been using the predetermined drug for at least a predetermined time period.

30. The method of claim 23, wherein step (c) further comprises generating the protocol to prescribe a treatment plan for the predetermined drug.

31. The method of claim 23, wherein step (d) further comprises communicating, by the device via a network, the protocol to a patient at an online community.

32. The method of claim 23, wherein step (e) further comprises submitting, by the patient, via an online site, information on symptom relief based on following the protocol.

33. The method of claim 23, further comprising analyzing the data received from the selected plurality of patents to determine results of the trial study.