Device and Method for Determining Activity of Radiopharmaceutical Material

• US 20120074330A1
• Filed: 12/14/2009
• Published: 03/29/2012
• Est. Priority Date: 06/05/2009
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Medrad Incorporated (Bayer AG)
• Inventors: Bouton, Chad E., Uber, Arthur E. III
• Granted Patent: US 8,198,599 B2
• Time in Patent Office: Days
• US Class Current: 250/393
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: G01T 7/02 Collecting means for receiving or storing samples to be investigated and possibly directly transporting the samples to the measuring arrangement; particularly for investigating radioactive fluids sampling, preparing specimens for investigation in general G01N1/00, G01N1/02; shielded cells or rooms structurally combined with manipulatin devices G21F; measuring of chromatographically separated samples G01N30/00 - G01N30/96

Abstract

A detector system measures radioactive material. A fluid path receives at least one aliquot of radiopharmaceutical. The fluid path locates the aliquot within a positioner formed with a concave configuration. A detector is located at an axial distance from the concave surface and determines the level of radioactivity of the aliquot. Alternatively, the fluid path may be less concave and a variable attenuator may be placed between the fluid path and detector. The variable attenuator may have a concavity that is based on the concavity of the fluid path so that the detector'"'"'s ability to read the radioactivity is optimized. A method for forming an aliquot of radiopharmaceutical in a concave fluid passage. Positioning a detector located a distance from the concave surface to optimize reading spectral energy of the aliquot and activity is determining activity regardless of the position of the aliquot in the passage.

Claims

1. A system for measuring radioactive material, comprising:

a fluid path for receiving at least one aliquot;

an aliquot positioner formed with a concave surface and connected to the fluid path and capable of receiving the at least one aliquot therefrom; and

a detector located at an axial distance from the aliquot positioner and operable to determine the level of radioactivity of the at least one aliquot disposed in the aliquot positioner.

3. The system of claim 1 wherein the detector is proximal to a concave side of the aliquot positioner.

4. The system of claim 1 wherein the aliquot positioner includes a passage formed as a coiled, spiral or serpentine configuration.

5. The system of claim 1 further including an output assembly connected to an output of the aliquot positioner.

6. The system of claim 1 further including a liquid source of radiopharmaceutical in fluid communication with the fluid path.

7. The system of claim 1 further including at least one optical element disposed between the aliquot positioner and the detector.

8. The system of claim 1 wherein the aliquot positioner has a surface based on a parabolic, spherical or dual cubic model.

9. The system of claim 1 wherein the aliquot positioner includes a tubular conduit.

10. The system of claim 1 wherein the aliquot positioner includes a bag.

11. The system of claim 1 further including an injector connected to the fluid path.

12. A system for measuring radioactive material, comprising:

a fluid path for receiving at least one aliquot releasing radioactive energy;

a selectable positioner directing the radioactive energy; and

a detector located at a distance from the selectable positioner and operable to determine the level of radioactivity of the at least one aliquot disposed in the selectable positioner,

wherein the selectable positioner includes at least one of a variable attenuator or a aliquot positioner having a concave configuration.

13. The system of claim 12 wherein a curvature of the at least variable attenuator and a curvature of the aliquot positioner are varied to optimize radiation detection by the detector.

14. The system of claim 12 wherein the variable attenuator includes channels extending in a radial direction therethrough thereby forming a collimator array.

15. The system of claim 14 wherein the channels are formed of varied diameters.

16. The system of claim 15 wherein the varied diameters are smallest toward a center and larger at a periphery of the variable attenuator.

17. The system of claim 12 wherein the variable attenuator includes a first collimator and a second collimator.

18. A method for measuring activity of an aliquot, comprising:

forming an aliquot in a concave shaped fluid passage;

providing a detector a distance from the concave shaped surface; and

reading spectral energy of the aliquot thereby determining the activity.

19. The method of claim 18 further including inserting an optical element between the concave shaped fluid passage and the detector.

20. The method of claim 18 further including collimating the spectra energy before reading the activity.