Method and Apparatus for Removing Blood Clots and Tissue from the Patient's Head

• US 20120078140A1
• Filed: 12/06/2011
• Published: 03/29/2012
• Est. Priority Date: 06/24/2005
• Status: Abandoned Application

• Current Assignee: Penumbra, Inc.
• Original Assignee: Penumbra, Inc.
• Inventors: Nita, Henry
• Application Number:
  US13/312,624
• Publication Number:
  US 20120078140A1
• Time in Patent Office: Days
• US Class Current: 601/2
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

Methods and apparatus for removing blood clots and tissue from intracranial space of the patient'"'"'s head using an ultrasound device under visualization guidance to locate, dissolve and remove the blood clots outside the patient'"'"'s head are provided. One or more pharmacologic agents may be delivered to the treatment area to further facilitate removal of the blood clots or other tissue.

Claims

1. A method for removing blood clots from a patient'"'"'s intracranial space using ultrasound energy, the method comprising:

forming at least one aperture in the patient'"'"'s skull;

advancing an ultrasound device having a visualization feature through the aperture to a target location within the intracranial space;

transmitting ultrasound energy at frequencies between 1 KHz and 20 MHz from the ultrasound device; and

removing blood clots outside the patient'"'"'s head.

2. The method of claim 1, wherein the aperture in the skull is selected from the group consisting of:

a craniotomy, a burr hole or a twist hole.

3. The method of claim 1, further include removing one of the following;

brain tissue, tumor tissue, cerebrospinal fluid, blood, blood clots or combination of all.

4. The method of claim 1, wherein the ultrasound device is placed through an introducer.

5. The method of claim 1, wherein the ultrasound device is placed through a frameless trajectory guide.

6. The method of claim 1, wherein a visualization feature recognizes blood clots in the intracranial space.

7. The method of claim 1, wherein the visualization feature is separate from the ultrasound device.

8. The method of claim 1, wherein the visualization feature comprises an electronic camera positioned on the distal end of the ultrasound device.

9. The method of claim 1, wherein the visualization feature comprises a diagnostic ultrasound visualization component located on the distal end of the ultrasound device.

10. The method of claim 1, wherein the visualization feature comprises an OCT visualization component located on the distal end of the ultrasound device.

11. The method of claim 1, further including repositioning the ultrasound device within the intracranial space.

12. The method of claim 11, wherein repositioning of the ultrasound device is achieved using a deflection, actuation, angulation or pre-shaped telescopic member, or a combination thereof.

13. The method of claim 11, wherein repositioning the ultrasound device comprises advancing the ultrasound device into the one of the following:

into the patient'"'"'s epidural space, into a ventricle of the patient'"'"'s brain, into an intracerebral space of the patient'"'"'s brain, or underneath the dura mater of the patient'"'"'s brain.

14. The method of claim 1, wherein advancing the ultrasound device comprises advancing a device selected from the group consisting of an ultrasound transducer, an ultrasound catheter with a proximal transducer, a transducer-tipped ultrasound catheter, and an ultrasound catheter having multiple transducers located on the distal portion of the catheter.

15. The method of claim 1, further comprising delivering at least one pharmacologic agent to the patient.

16. The method of claim 15, wherein the agent is selected from a group consisting of blood clot reducing agents such as (i) tissue plasminogen activator, tPA, BB-10153, rTPA, Urokinease, Streptokinase, Alteplase and Desmoteplase, (ii) antiplatelet agents such as aspirin, Clopidorgel and Ticclopidine, and (iii) GIIb/IIIa inhibitors, such as Abciximab, Tirofiban and Eptifibatide.

17. The method of claim 1, further comprising delivering microbubbles or nanobubbles to the patient.

18. The method of claim 1, further including delivering irrigation medium through the ultrasound device while transmitting ultrasound energy.

19. The method of claim 1, wherein removal of blood clots to the outside of the patient'"'"'s head is accomplish using aspiration.

20. A method for removing blood clots from a patient'"'"'s intracranial space caused by hemorrhage, comprising the step of advancing an ultrasound device into the patient'"'"'s head, identifying blood clots with a visualization feature, transmitting ultrasound energy at frequencies between 1 KHz and 20 MHz, and removing blood clots outside the head.

21. A method for removing tissue from a patient'"'"'s intracranial space comprising the step of advancing an ultrasound device into the patient'"'"'s head, identifying tissue to be removed using a visualization feature, transmitting ultrasound energy at frequencies between 1 KHz and 20 MHz, and removing tissue outside the head.

22. The method of claim 21, wherein the ultrasound device has a deflectable feature that reaches and removes tissue located away from the aperture.

23. A method for removing tissue from a patient'"'"'s intracranial space comprising the step of advancing a visualization device into the patient'"'"'s head to identify tissue to be removed, placing an ultrasound device into the treatment area, transmitting ultrasound energy at frequencies between 1 KHz and 20 MHz, and removing tissue outside the head.

24. A method for removing blood clots from a patient'"'"'s intracranial space using a therapeutic apparatus, the method comprising:

forming at least one aperture in the patient'"'"'s skull;

advancing a therapeutic apparatus having a visualization feature and an ultrasound feature through the aperture to a target location within the intracranial space;

identifying blood clots;

transmitting ultrasound energy from the ultrasound device; and

removing blood clots outside the patient'"'"'s head.

25. The method of claim 24, wherein the therapeutic apparatus has an ultrasound device and a visualization device that can be advanced to the intracranial space separately.