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Apparatus for electrically mediated delivery of therapeutic agents

  • US 20120078161A1
  • Filed: 03/08/2005
  • Published: 03/29/2012
  • Est. Priority Date: 03/08/2004
  • Status: Active Grant
First Claim
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1. An apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient comprising:

  • a) a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes;

    b) structural means incorporating an inanimate source of energy operatively connected to said plurality of electrodes for deploying said electrodes, and wherein said source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kg/square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of said electrodes; and

    c) means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.

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