System and method for diagnosis tissue samples using fluorescence and raman techniques
First Claim
1. A method comprising:
- illuminating a test biological sample to thereby generate a first plurality of interacted photons;
detecting said first plurality of interacted photons to thereby generate at least one fluorescence data set representative of said sample;
analyzing said fluorescence data set to thereby determine at least one region of interest of said sample;
illuminating said region of interest to thereby generate a second plurality of interacted photons;
detecting said second plurality of interacted photons to thereby generate at least one Raman data set representative of said region of interest;
analyzing said Raman data set to thereby determine a diagnosis, wherein said diagnosis is selected from the group consisting of;
a metabolic state of said sample, a clinical outcome of said sample, a disease progression of said sample, a disease state of said sample, and combinations thereof.
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Abstract
A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.
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Citations
29 Claims
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1. A method comprising:
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illuminating a test biological sample to thereby generate a first plurality of interacted photons; detecting said first plurality of interacted photons to thereby generate at least one fluorescence data set representative of said sample; analyzing said fluorescence data set to thereby determine at least one region of interest of said sample; illuminating said region of interest to thereby generate a second plurality of interacted photons; detecting said second plurality of interacted photons to thereby generate at least one Raman data set representative of said region of interest; analyzing said Raman data set to thereby determine a diagnosis, wherein said diagnosis is selected from the group consisting of;
a metabolic state of said sample, a clinical outcome of said sample, a disease progression of said sample, a disease state of said sample, and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A storage medium containing machine readable program code, which, when executed by a processor, causes said processor to perform the following:
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illuminate a test biological sample to thereby generate a first plurality of interacted photons; detect said first plurality of interacted photons to thereby generate at least one fluorescence data set representative of said sample; analyze said fluorescence data set to thereby determine a region of interest of said sample; illuminate said region of interest to thereby generate a second plurality of interacted photons; detect said second plurality of interacted photons to thereby generate at least one Raman data set representative of said region of interest; and analyze said Raman data set to thereby determine at least one of;
a metabolic state of said sample, a clinical outcome of said sample, a disease progression of said sample, a disease state of said sample, and combinations thereof. - View Dependent Claims (19, 20)
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21. A system comprising:
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a first illumination source configured so as to illuminate a test biological sample to thereby generate a first plurality of interacted photons; a first detector configured so as to detect said first plurality of interacted photons and generate at least one fluorescence data set representative of said sample; a means for analyzing said fluorescence data set to thereby determine a region of interest of said test biological sample; and a second illumination source configured so as to illuminate a region of interest of said biological sample to thereby generate a second plurality of interacted photons; a second detector configured so as to detect said second plurality of interacted photons and generate at least one Raman data set representative of said region of interest; and a means for analyzing said Raman data set to thereby determine a diagnosis selected from the group consisting of;
a metabolic state of said sample, a clinical outcome of said sample, a disease progression of said sample, a disease state of said sample, and combinations thereof. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
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Specification