MEDICAL DEVICES HAVING POLYMERIC REGIONS WITH COPOLYMERS CONTAINING HYDROCARBON AND HETEROATOM-CONTAINING MONOMERIC SPECIES

• US 20120083523A1
• Filed: 12/08/2011
• Published: 04/05/2012
• Est. Priority Date: 02/01/2005
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: FAUST, Rudolf, RICHARD, Robert E., SCHWARZ, Marlene C.
• Granted Patent: US 8,992,512 B2
• Time in Patent Office: Days
• US Class Current: 514/449
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: C08L 53/00 Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Abstract

According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.

Claims

1. A medical device comprising a polymeric region, said polymeric region comprising an elastomeric block copolymer that comprises:

(a) a first polymer block comprising an unsaturated hydrocarbon monomer species and (b) a second polymer block comprising a heteroatom-containing monomer species, with the proviso that said second block does not comprise a heteroatom-containing monomer species selected from protected hydroxystyrene monomer species, maleic anhydride monomer species, methyl methacrylate monomer species, ethyl methacrylate monomer species and hydroxyethyl methacrylate monomer species, said medical device being adapted for implantation or insertion into a subject'"'"'s body.

3. The medical device of claim 1, wherein said first block comprises two or more unsaturated hydrocarbon monomer species.

4. The medical device of claim 3, wherein said first block comprises ethylene and butylene.

5. The medical device of claim 1, wherein said first block comprises an olefin monomer species.

6. The medical device of claim 5, wherein said first block comprises isobutylene.

8. The medical device of claim 1, wherein said second block comprises a vinyl pyridine monomer species.

9. The medical device of claim 8, wherein said vinyl pyridine monomer species is 2-vinyl pyridine.

20. The medical device of claim 1, wherein said medical device further comprises a therapeutic agent disposed within or beneath said polymeric region.

21. The medical device of claim 20, wherein said therapeutic agent is disposed beneath said polymeric region.

22. The medical device of claim 20, wherein said therapeutic agent is disposed within said polymeric region.

23. The medical device of claim 1, wherein said polymer region further comprises an additional polymer in addition to said copolymer, and wherein said additional polymer is blended with said copolymer.

24. The medical device of claim 1, wherein said polymer region further comprises an additional polymer in addition to said copolymer, and wherein said additional polymer is attached to said copolymer.

25. The medical device of claim 1, wherein said polymeric region is disposed over a substrate.

26. The medical device of claim 1, wherein said medical device is selected from a guide wire, a balloon, a vena cava filter, a catheter, a stent, a stent graft, a vascular graft, a cerebral aneurysm filler coil, a myocardial plug, a heart valve, a vascular valve, and a tissue engineering scaffold.

27. The medical device of claim 1, wherein said therapeutic agent is selected from anti-thrombotic agents, anti-proliferative agents, anti-inflammatory agents, anti-migratory agents, agents affecting extracellular matrix production and organization, antineoplastic agents, anti-mitotic agents, anesthetic agents, anti-coagulants, vascular cell growth promoters, vascular cell growth inhibitors, cholesterol-lowering agents, vasodilating agents, and agents that interfere with endogenous vasoactive mechanisms.

2. The medical device of claim 2, wherein said second block comprises monomer species selected from vinyl amine monomer species, POSS monomer species, hydroxystyrene monomer species, vinyl alcohol, high T_g vinyl ether monomer species, and combinations of the same.

7. The medical device of claim 2, wherein said second block comprises said vinyl amine monomer species.

10. The medical device of claim 2, wherein said second block comprises said POSS monomer species.

11. The medical device of claim 10, wherein said POSS monomer species is a styryl-POSS monomer species.

12. The medical device of claim 10, wherein said first block comprises polyisobutylene.

13. The medical device of claim 2, wherein said second block comprises said hydroxystyrene monomer species.

14. The medical device of claim 2, wherein said second block comprises said high T_g vinyl ether monomer species.

15. The medical device of claim 14, wherein said high T_g vinyl ether monomer species is hydrolysable in acid or base.

16. The medical device of claim 14, wherein said high T_g vinyl ether monomer species is non-hydrolysable in acid or base.

17. The medical device of claim 14, wherein said high T_g vinyl ether monomer species is selected from tert-butyl vinyl ether, neopentyl vinyl ether, cyclohexyl vinyl ether, benzyl vinyl ether, tert-butyldimethylsilyl vinyl ether, and mixtures thereof.

18. The medical device of claim 14, wherein said second block comprises said high T_g vinyl ether monomer species and said first block comprises an olefin monomer species.

19. The medical device of claim 18, wherein said second block is a poly(hydrolysable high T_g vinyl ether) block, a poly(non-hydrolysable high T_g vinyl ether) block or a poly(hydrolysable high T_g vinyl ether-co-non-hydrolysable high T_g vinyl ether) block, and wherein said first block is a polyisobutylene block.

28. A medical device comprising a polymeric region, said polymeric region comprising a copolymer that comprises:

(a) an unsaturated hydrocarbon monomer species and (b) a POSS monomer species, said medical device being adapted for implantation or insertion into a subject'"'"'s body.