METHOD OF DELIVERING MATERIAL OR STIMULUS TO A BIOLOGICAL SUBJECT
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Accused Products
Abstract
A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
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Citations
78 Claims
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1-45. -45. (canceled)
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46. A method of delivering material or stimulus to a biological subject, the method comprising applying a device to the biological subject, the device comprising:
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a) a base; and b) projections extending from the base, wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m; andiv) projections are separated by a spacing of between 10 μ
m and 200 μ
m. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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68. A method of delivering vaccine to a biological subject to produce an immunological response, the method comprising applying a device to the biological subject, the device comprising:
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a) a base; and b) projections extending from the base, wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m;iv) projections are separated by a spacing of between 10 μ
m and 200 μ
m; andv) one or more of the projections are at least partially coated with a vaccine. - View Dependent Claims (69, 70)
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71. A method for delivering material to a biological subject, the method comprising applying a device to the biological subject, the device comprising:
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a) a base; and b) projections extending from the base, wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein at least part of at least some of the projections is coated, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m; andiv) projections are separated by a spacing of between 10 μ
m and 200 μ
m. - View Dependent Claims (72, 73)
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74. A method for delivering stimulus to a biological subject, the method comprising applying a device to the biological subject, the device comprising:
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a) a base; and b) projections extending from the base, wherein each projection comprises a tip for penetrating a surface of the biological surface, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m; andiv) projections are separated by a spacing of between 10 μ
m and 200 μ
m. - View Dependent Claims (75)
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76. A method of treating a biological subject, the method comprising applying a skin penetrating device to a biological subject, the device comprising:
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a) a base; and b) a number of projections extending from the base, wherein the projections are arranged in an array, and wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m; andiv) projections are separated by a spacing of between 10 μ
m and 200 μ
m.
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77. A method of treating a biological subject, the method comprising using a device for delivery of material or stimulus biological subject, the device comprising:
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a) a base; and b) projections extending from the base, wherein each projection comprises a tip for penetrating a surface of the biological subject, and wherein; i) the number of projections is at least 500; ii) each projection has a length of between 200 μ
m and 1000 μ
m;iii) each projection has a base width of between 5 μ
m and 50 μ
m; andiv) projections are separated by a spacing of between 10 μ
m and 200 μ
m.
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78. A method of treating a subject, the method comprising using a device for delivery of material or stimulus to targets within the subject'"'"'s body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest, the device comprising a number of projections for penetrating a body surface, and wherein:
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a) the number of projections is selected to produce a desired response, the number being at least 500; and
,b) a spacing between projections is at least partially determined based on an arrangement of the targets within the body.
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Specification