FLUID DELIVERY MANIFOLDS AND MICROFLUIDIC SYSTEMS
First Claim
Patent Images
1. A fluid distribution manifold comprising:
- an insert member having a shape and a first surface and a second surface, wherein the insert member at least partially defines at least one channel in the first surface, wherein the at least one channel is configured for fluid communication between an inlet location and a plurality of outlet locations;
a manifold base having a first surface and a second surface, wherein the manifold base at least partially defines an indentation in the first surface having the shape and configured to receive the insert member, such that if the insert member is press-fit into the manifold base, the at least one channel forms a substantially closed channel with a surface of the manifold base; and
wherein at least one of the manifold base and the insert member at least partially defines a fluid inlet from the first surface to the second surface and in fluid communication with the inlet location, and wherein at least one of the manifold base and the insert member at least partially defines a plurality of fluid outlets from the first surface to the second surface, wherein ones of the fluid outlets are in fluid communication with the respective outlet locations.
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Accused Products
Abstract
Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
10 Citations
30 Claims
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1. A fluid distribution manifold comprising:
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an insert member having a shape and a first surface and a second surface, wherein the insert member at least partially defines at least one channel in the first surface, wherein the at least one channel is configured for fluid communication between an inlet location and a plurality of outlet locations; a manifold base having a first surface and a second surface, wherein the manifold base at least partially defines an indentation in the first surface having the shape and configured to receive the insert member, such that if the insert member is press-fit into the manifold base, the at least one channel forms a substantially closed channel with a surface of the manifold base; and wherein at least one of the manifold base and the insert member at least partially defines a fluid inlet from the first surface to the second surface and in fluid communication with the inlet location, and wherein at least one of the manifold base and the insert member at least partially defines a plurality of fluid outlets from the first surface to the second surface, wherein ones of the fluid outlets are in fluid communication with the respective outlet locations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A cartridge for use with a microfluidic chip, the cartridge comprising:
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a manifold at least partially defining at least one fluid reservoir configured for fluid communication with the microfluidic chip, wherein the at least one fluid reservoir has an inlet and an outlet; and an electrical interconnect board defining at least one through-hole having a conductive sidewall in fluid communication with the fluid reservoir, wherein the conductive sidewall is configured to apply a voltage to a fluid in the reservoir. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A microfluidic system comprising:
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a cartridge comprising; a microfluidic chip; a manifold at least partially defining at least one fluid reservoir configured for fluid communication with the microfluidic chip, wherein the at least one fluid reservoir has an inlet and an outlet; an electrical interconnect board defining at least one through-hole having a conductive sidewall in fluid communication with the fluid reservoir, wherein the conductive sidewall is configured to apply a voltage to a fluid in the reservoir; and a frame having at least one magnetized area, the frame at least partially supporting the manifold; and an electrical multiplex board comprising; a plurality of electrodes, at least one in electronic communication with the conductive sidewall of the through-hole; a plurality of voltage relays, wherein the plurality of voltage relays are configured to couple one or more of the electrodes to at least one voltage source in accordance with control signals; and at least one magnet forming a magnetic connection with the frame. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. A method for conducting a microfluidic analysis, the method comprising:
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removeably magnetically latching a cartridge including a microfluidic chip to an electrical multiplex board; applying a voltage to at least one fluid reservoir in cartridge through the electrical multiplex board; routing at least one fluid through a press-fit fluid manifold in the cartridge; and detecting a signal from the microfluidic chip. - View Dependent Claims (29, 30)
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Specification