NEUROSTIMULATION SYSTEM AND METHOD FOR PROVIDING THERAPY TO PATIENT WITH MINIMAL SIDE EFFECTS
First Claim
1. A method of providing therapy to a tissue region of a patient using first and second electrodes, comprising:
- conveying an electrical pulsed waveform between the first electrode and a stimulation site of a spinal cord of the patient, thereby evoking the antidromic propagation of action potentials along at least one sensory neural fiber of the spinal cord that creates a therapeutic effect in the tissue region, and evoking the orthodromic propagation of action potentials along the at least one sensory neural fiber that potentially creates a sensation of paresthesia in the brain of the patient corresponding to the tissue region; and
conveying electrical energy between the second electrode and a blocking site of the spinal cord rostral to the stimulation site, thereby blocking the orthodromically propagated action potentials and reducing the paresthesia that would have otherwise been caused in the patient in the absence of the conveyed electrical energy.
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Abstract
A method comprises conveying a pulsed waveform between an electrode and a stimulation site of a spinal cord, thereby evoking the antidromic propagation of action potentials along a first sensory neural fiber creating a therapeutic effect in the tissue region, evoking the orthodromic propagation of action potentials along the first sensory neural fiber potentially creating paresthesia corresponding to the tissue region, and evoking the antidromic propagation of action potentials along a second sensory neural fiber potentially creating a side-effect in another tissue region. The method further comprises conveying electrical energy between an electrode and a blocking site rostral to the stimulation site, thereby blocking the action potentials propagated along the first sensory neural fiber and reducing the paresthesia, and conveying electrical energy between an electrode and a blocking site caudal to the stimulation site, thereby blocking the action potentials propagated along the second sensory neural fiber and reducing the side-effect.
110 Citations
22 Claims
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1. A method of providing therapy to a tissue region of a patient using first and second electrodes, comprising:
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conveying an electrical pulsed waveform between the first electrode and a stimulation site of a spinal cord of the patient, thereby evoking the antidromic propagation of action potentials along at least one sensory neural fiber of the spinal cord that creates a therapeutic effect in the tissue region, and evoking the orthodromic propagation of action potentials along the at least one sensory neural fiber that potentially creates a sensation of paresthesia in the brain of the patient corresponding to the tissue region; and conveying electrical energy between the second electrode and a blocking site of the spinal cord rostral to the stimulation site, thereby blocking the orthodromically propagated action potentials and reducing the paresthesia that would have otherwise been caused in the patient in the absence of the conveyed electrical energy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of providing therapy to a tissue region of a patient using first and second electrodes, comprising:
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conveying an electrical pulsed waveform between the first electrode and a stimulation site of a spinal cord of the patient, thereby evoking the antidromic propagation of action potentials along at least a first sensory neural fiber of the spinal cord that creates a therapeutic effect in the tissue region, and evoking the antidromic propagation of action potentials along at least another sensory neural fiber of the spinal cord that potentially creates a side-effect in another tissue region, wherein the at least first sensory neural fiber terminates in a dorsal horn of the spinal cord at a first vertebral level, and the at least second sensory neural fiber terminates in dorsal horn at a second vertebral level caudal to the first vertebral level; and conveying electrical energy between the second electrode and a blocking site of the spinal cord between the first and second vertebral levels, thereby blocking the action potentials antidromically propagating along the at least second sensory neural fiber and reducing the side-effect that would have otherwise been caused in the patient in the absence of the conveyed electrical energy. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification