Use of Monoamine Oxidase Inhibitors to Improve Epithelial Biology

• US 20120093752A1
• Filed: 10/13/2011
• Published: 04/19/2012
• Est. Priority Date: 10/15/2010
• Status: Active Grant

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Youngquist, Robert Scott, Binder, Robert Lloyd, Fuentes, Gary Richard, DiColandrea, Teresa, Xie, Sancai, Lade, Deborah
• Granted Patent: US 8,986,664 B2
• Time in Patent Office: Days
• US Class Current: 424/70.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/138 Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine atenolol A61K31/165; pindolol A61K31/404; timolol A61K31/5377
• CPC Class Codes: A61K 31/435 having six-membered rings with one nitrogen as the only ring hetero atom
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/4926 having six membered rings
• CPC Class Codes: A61K 8/4953 containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.

Claims

1. A method for improving hair growth in a subject, the method comprising administering to a subject a monoamine oxidase (MAO) inhibitor and a vasodilator in an amount effective to improve hair growth.

2. The method of claim 1, wherein the vasodilator is minoxidil.

3. The method of claim 1, wherein the MAO inhibitor is an MAOB inhibitor.

4. The method of claim 3, wherein the MAO inhibitor is a reversible MAOB inhibitor.

5. The method of claim 3, wherein the MAO inhibitor is an irreversible MAOB inhibitor.

6. The method of claim 1, wherein the MAO inhibitor is selected from the group consisting of clorgiline, paragyline, lazabemide, selegiline, phenelzine, rasagiline, and combinations thereof.

8. The method of claim 1, wherein the method improves hair growth to a greater degree than administering the MAO inhibitor or vasodilator alone.

9. The method of claim 1, wherein the subject suffers from hair loss that is not associated with androgenetic alopecia.

10. The method of claim 1, wherein the subject is not responsive or minimally responsive to vasodilator treatment alone.

11. The method of claim 1, comprising topically administering the MAO inhibitor and vasodilator to the subject.

7. The method of any 1, comprising administering the MAO inhibitor and the vasodilator concurrently.

12. A method for improving hair biology, the method comprising administering to a subject (a) a monoamine oxidase (MAO) inhibitor and (b) one or more agents selected from the group consisting of a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil and adenosine, in an amount effective to improve hair biology.

13. The method of claim 12, wherein improving hair biology comprises increasing hair count, increasing hair diameter, increasing hair strength, increasing hair shine, and/or increasing hair curl.

14. A method of reducing or delaying the appearance of an age-related skin imperfection in a subject, the method comprising topically administering to the subject a composition comprising an MAO inhibitor selected from the group consisting of clorgiline, paraglyine, lazabemide, selegyline, phenylzine, rasagiline, and combinations thereof in an amount effective to reduce or delay the appearance of an age-related skin imperfection,

wherein the composition does not comprise an iron chelator, an antiapoptotic agent other than the MAO inhibitor, a neuroprotective agent other than the MAO inhibitor, cholinesterase inhibitor, or an N-methyl-D-aspartic acid (NMDAR) receptor inhibitor.

15. The method of claim 14, wherein the age-related skin condition is selected from the group consisting of wrinkles, fine lines, dryness, roughness, loss of elasticity, loss of volume, hyperpigmentation.

16. A kit comprising a composition comprising (a) a monoamine oxidase (MAO) inhibitor and, in the same composition or in a different composition, a vasodilator, in an amount effective to improve hair growth, and (b) instructions for applying said composition(s) to the skin of a subject.

17. The kit of claim 16, wherein the vasodilator is minoxidil.

18. The kit of claim 16 or claim 17, wherein the MAO inhibitor is an MAOB inhibitor.

19. The kit of claim 18, wherein the MAO inhibitor is an irreversible MAOB inhibitor.

20. The kit of claim 18, wherein the MAO inhibitor is a reversible MAOB inhibitor.

21. The kit of claim 16, wherein the MAO inhibitor is selected from the group consisting of clorgiline, paraglyine, lazabemide, selegyline, phenylzine, and rasagiline.