Use of Monoamine Oxidase Inhibitors to Improve Epithelial Biology
First Claim
1. A method for improving hair growth in a subject, the method comprising administering to a subject a monoamine oxidase (MAO) inhibitor and a vasodilator in an amount effective to improve hair growth.
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Abstract
The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.
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Citations
21 Claims
- 1. A method for improving hair growth in a subject, the method comprising administering to a subject a monoamine oxidase (MAO) inhibitor and a vasodilator in an amount effective to improve hair growth.
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7. The method of any 1, comprising administering the MAO inhibitor and the vasodilator concurrently.
- 12. A method for improving hair biology, the method comprising administering to a subject (a) a monoamine oxidase (MAO) inhibitor and (b) one or more agents selected from the group consisting of a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil and adenosine, in an amount effective to improve hair biology.
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14. A method of reducing or delaying the appearance of an age-related skin imperfection in a subject, the method comprising topically administering to the subject a composition comprising an MAO inhibitor selected from the group consisting of clorgiline, paraglyine, lazabemide, selegyline, phenylzine, rasagiline, and combinations thereof in an amount effective to reduce or delay the appearance of an age-related skin imperfection,
wherein the composition does not comprise an iron chelator, an antiapoptotic agent other than the MAO inhibitor, a neuroprotective agent other than the MAO inhibitor, cholinesterase inhibitor, or an N-methyl-D-aspartic acid (NMDAR) receptor inhibitor.
- 16. A kit comprising a composition comprising (a) a monoamine oxidase (MAO) inhibitor and, in the same composition or in a different composition, a vasodilator, in an amount effective to improve hair growth, and (b) instructions for applying said composition(s) to the skin of a subject.
Specification