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COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF HUNTINGTIN GENE

  • US 20120095076A1
  • Filed: 10/04/2011
  • Published: 04/19/2012
  • Est. Priority Date: 10/28/2005
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising a double stranded ribonucleic acid (dsRNA) comprising a sense strand and an antisense strand and a pharmaceutically acceptable carrier, antisense strand comprises a nucleotide sequence consisting of SEQ ID NO:

  • 793 and a 2′

    -O-methyl modified nucleotide at location 4 and the sense strand comprises a nucleotide sequence consisting of SEQ ID NO;

    792 and a 2′

    -O-methyl modified nucleotide at locations 2, 3, 5, 12, 13, 15, and 17.

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