OPHTHALMIC COMPOSITION

• US 20120095097A1
• Filed: 06/25/2009
• Published: 04/19/2012
• Est. Priority Date: 06/25/2009
• Status: Active Grant

• Current Assignee: Lion Corporation
• Original Assignee: Lion Corporation
• Inventors: Tabuchi, Nobuhito, Inoue, Chieko, Hattori, Manabu, Miyake, Miyuki, Tsutsui, Hazuki
• Granted Patent: US 9,012,503 B2
• Time in Patent Office: Days
• US Class Current: 514/552
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/23 of acids having a carboxyl group bound to a chain of seven or more carbon atoms
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

Disclosed is an ophthalmic composition containing (A) not less than 50,000 units/100 mL of vitamin A, (B) not less than 0.4 W/V % of a polyoxyethylene polyoxypropylene glycol, and (C) trometamol.

Claims

1. An ophthalmic composition comprising (A) at least 50,000 units/100 mL of vitamin A, (B) at least 0.4 W/V % of polyoxyethylene polyoxypropylene glycol and (C) trometamol.

2. The ophthalmic composition as defined in claim 1, wherein a content of the ingredient (A) is at least 100,000 units/100 mL.

3. The ophthalmic composition as defined in claim 1, wherein a content of the ingredient (A) is at least 200,000 units/100 mL.

4. The ophthalmic composition as defined in claim 1, wherein a content of the ingredient (A) is at least 300,000 units/100 mL.

5. The ophthalmic composition as defined in any one of claims 1 to 4, further comprising (D) an antioxidant.

6. The ophthalmic composition as defined in claim 5, wherein the ingredient (D) is vitamin E and/or dibutylhydroxytoluene.

7. The ophthalmic composition as recited in claim 1, wherein the ingredient (A) is retinol palmitate, retinol acetate or retinoic acid.

8. The ophthalmic composition as defined in claim 1, wherein a ratio by weight between the ingredient (B) and the ingredient (C) expressed as (B):

(C) is at 1;

30 to 30;

1.

9. A method for stabilizing vitamin comprising:

formulating at least 0.4 W/V % of polyoxyethylene polyoxypropylene glycol and (C) trometamol in an ophthalmic composition containing at least 50,000 units/100 mL of vitamin A.