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METHOD FOR PRODUCING CROSS-LINKED HYALURONIC ACID

  • US 20120095206A1
  • Filed: 12/12/2011
  • Published: 04/19/2012
  • Est. Priority Date: 04/09/2009
  • Status: Active Grant
First Claim
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1. A method for producing a cross-linked hyaluronic acid comprising:

  • (a) cross-linking at least one polymer at a temperature, from about 35°

    C. to about 60°

    C., for a reaction time of from about 0.1 hour to about 72 hours with a cross-linking agent; and

    (b) lowering the temperature in step (a) to from about 10°

    C. to about 30°

    C. for a reaction time of from about 48 hours to about 28 days to obtain the cross-linked hyaluronic acid,wherein the steps (a) and (b) are conducted under a basic condition;

    the polymer is selected from the group consisting of hyaluronic acid, hyaluronate, carboxymethylcellulous (CMC), alginate, chondroitin-4-sulfate, chondroitin-6-sulfate, xanthane gum, chitosan, pectin, agar, carrageenan and guar gum thereof and a mixture thereof; and

    the method is absent a step of purifying the cross-linked hyaluronic acid and the content of the cross-linking agent with free-state functional group is below about 300 ppm in the cross-linked hyaluronic acid.

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