Spectrophotometric Monitoring Of Multiple Layer Tissue Structures
First Claim
1. A method for non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers including a relatively deep tissue layer, comprising:
- receiving at least one measured absorption property and at least one measured scattering property for each of a plurality of predetermined source-detector separation distances of an aggregrate near-infrared spectrophotometric (NIRS) tissue monitor as applied along a surface of the biological volume, the aggregate NIRS tissue measurements being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume;
receiving a predetermined multi-layer tissue model that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured by the aggregate NIRS tissue monitor at selected source-detector separation distances along a surface thereof; and
processing said measured absorption and scattering properties of said biological volume for said plurality of predetermined source-detector separation distances in conjunction with said predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers are described. Aggregate absorption and scattering properties are measured for each of a plurality of predetermined source-detector separation distances along a surface of the biological volume, the measurement being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume. A predetermined multi-layer tissue model is retrieved that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured at selected source-detector separation distances along a surface thereof. The measured aggregate absorption and scattering properties are processed in conjunction with the predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer.
-
Citations
20 Claims
-
1. A method for non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers including a relatively deep tissue layer, comprising:
-
receiving at least one measured absorption property and at least one measured scattering property for each of a plurality of predetermined source-detector separation distances of an aggregrate near-infrared spectrophotometric (NIRS) tissue monitor as applied along a surface of the biological volume, the aggregate NIRS tissue measurements being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume; receiving a predetermined multi-layer tissue model that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured by the aggregate NIRS tissue monitor at selected source-detector separation distances along a surface thereof; and processing said measured absorption and scattering properties of said biological volume for said plurality of predetermined source-detector separation distances in conjunction with said predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. An apparatus for non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers including a relatively deep tissue layer, comprising:
-
an aggregrate near-infrared spectrophotometric (NIRS) tissue monitor configured to measure at least one aggregate absorption property and at least one aggregate scattering property for each of a plurality of predetermined source-detector separation distances along a surface of the biological volume, wherein the aggregate NIRS monitor computes the said absorption and scattering properties based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume; a processing device programmed and configured to carry out the steps of; receiving the at least one aggregate absorption property and the at least one aggregate scattering property for each of the plurality of predetermined source-detector separation distances from the aggregate NIRS tissue monitor; receiving a predetermined multi-layer tissue model that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured by the aggregate NIRS tissue monitor at selected source-detector separation distances along a surface thereof; and processing said measured absorption and scattering properties of said biological volume for said plurality of predetermined source-detector separation distances in conjunction with said predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer; and a display device coupled to the processing device for outputting a display of at least one deep-layer-specific biological metric computed at least in part from said deep-layer-specific absorption property. - View Dependent Claims (12, 13, 14, 15, 16, 17)
-
-
18. A computer program product embodied on a computer-readable medium for non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers including a relatively deep tissue layer, comprising:
-
computer code for receiving at least one measured absorption property and at least one measured scattering property for each of a plurality of predetermined source-detector separation distances of an aggregrate near-infrared spectrophotometric (NIRS) tissue monitor as applied along a surface of the biological volume, the aggregate NIRS tissue measurements being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume; computer code for receiving a predetermined multi-layer tissue model that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured by the aggregate NIRS tissue monitor at selected source-detector separation distances along a surface thereof; and computer code for processing said measured absorption and scattering properties of said biological volume for said plurality of predetermined source-detector separation distances in conjunction with said predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer. - View Dependent Claims (19, 20)
-
Specification