Volume Sensing

• US 20120095355A1
• Filed: 03/13/2010
• Published: 04/19/2012
• Est. Priority Date: 03/13/2009
• Status: Abandoned Application

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark
• Application Number:
  US12/678,147
• Publication Number:
  US 20120095355A1
• Time in Patent Office: Days
• US Class Current: 600/508
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive

Abstract

Each sensor in one or more pairs of sensors is associated with a particular tissue, for example a first tissue location and a second tissue location respectively. Tissue at a particular tissue location may be solid, for example, muscle tissue, fat tissue, etc., or fluid, for example, blood, fluids associated with edema, etc. The area between the two tissue locations associated with a pair of sensors may comprise solid tissue, fluid tissue, an empty chamber, or combinations thereof. For each pair of sensors in the at least one pair of sensors, a first impedance measurement between the pair of sensors and associated with a first frequency is determined. For each pair of sensors in the at least one pair of sensors, a second impedance measurement between the pair of sensors and associated with a second frequency is determined. A comparison of a ratio of the first impedance measurement at a point in time to the second impedance measurement at a corresponding point in time may be made to determine a volume-related value associated with an area located between the first tissue location and the second tissue location.

Claims

1. A method for use with a lead having at least first and second electrodes, and for use with circuitry having means for measuring impedance between the at least first and second electrodes at least two distinct frequency bands, the lead initially being sterile and contained within a sterile wrapper, the method comprising the steps of:

removing the lead from the sterile wrapper;

implanting the lead within an organ; and

connecting the lead to the circuitry.

2. The method of claim 1 further comprising the steps, performed after the connecting step, of measuring impedance at the at least two distinct frequency bands between the at least first and second electrodes, thereby arriving at an indication of the liquid volume of the organ.

3. The method of claim 1 wherein the impedance measurements at the at least two distinct frequencies happens at respective and distinct times.

4. A method for use with a lead having at least first and second electrodes, the lead disposed within an organ, the lead connected to first circuitry lacking means for measuring impedance between the at least first and second electrodes at least two distinct frequency bands, the method comprising the steps of:

disconnecting the lead from the first circuitry, and

connecting the lead to second circuitry, the second circuitry having means for measuring impedance between the at least first and second electrodes

5. The method of claim 4 further comprising the step, performed after the connecting step, of measuring impedance at the at least two distinct frequency bands between the at least first and second electrodes, thereby arriving at an indication of the liquid volume of the organ.

6. The method of claim 4 wherein the emission of the energy at the at least two distinct frequencies happens at respective and distinct times.

7. A method for use with a lead having at least first and second electrodes, the lead implanted within an organ, and for use with circuitry having means for measuring impedance between the at least first and second electrodes, the method comprising the steps of:

measuring impedance at the at least two distinct frequency bands at the first and second electrodes, and

applying a function to the sensed impedances, thereby arriving at an indication of the liquid volume of the organ.

8. The method of claim 7 wherein the emission of the energy at the at least two distinct frequencies happens at respective and distinct times.

9. A system comprising:

a lead having at least first and second electrodes;

circuitry having means for measuring impedance between the at least first and second electrodes;

the lead being sterile and contained within a sterile wrapper.

10. The system of claim 9, the circuitry characterized in that the emission of the energy at the at least two distinct frequencies happens at respective and distinct times.

24. The method of claim 10 wherein the communicating the converted measurements to a destination device comprises employing at least one of a time multiplexing scheme and a frequency multiplexing scheme.

11. A system comprising:

a lead having at least first and second electrodes;

circuitry having means for measuring impedance between the at least first and second electrodes;

the lead implanted within an organ of a living subject and connected with the circuitry.

12. The system of claim 11, the circuitry characterized in that the emission of the energy at the at least two distinct frequencies happens at respective and distinct times.

13. The system of claim 11 wherein the circuitry is implanted within the subject.

14. A method comprising:

associating each sensor in at least one pair of sensors with a respective first tissue location and a respective second tissue location; and

for each pair of sensors in the at least one pair of sensors;

determining at a first point in time a first impedance measurement associated with a first frequency between the at least one pair of sensors;

determining at a second point in time a second impedance measurement associated with a second frequency between the at least one pair of sensors; and

comparing a ratio of the first impedance measurement to the second impedance measurement to determine a volume-related value associated with an area located between the first tissue location and the second tissue location.

15. The method of claim 14, wherein the area comprises at least one of a solid tissue and a fluid tissue.

16. The method of claim 15, wherein the fluid tissue comprises at least one of a blood tissue and a non-blood tissue.

17. The method of claim 14, wherein the area forms an empty chamber between the first tissue location and the second tissue location.

18. The method of claim 14, further comprising:

determining, over a first time interval, a first sequence of impedance measurements associated with a first frequency;

determining, over a second time interval, a second sequence of impedance measurements associated with a second frequency; and

comparing ratios of measurements of the first sequence to corresponding measurements of the second sequence to determine volume-related data and frequency data associated with an area located between the first tissue location and the second tissue location.

19. The method of claim 18, further comprising:

comparing each ratio of measurements associated with a each pair of sensors in the at least one pair of sensors to determine to determine volume-related data and frequency data associated with all the pairs of sensors in the at least one pair of sensors.

20. The method of claim 14, further comprising:

generating an electrical field of alternating current.

21. The method of claim 14, wherein the generating an electrical field associated with a body structure comprises at least one of:

applying the electrical field externally to the body structure; and

applying the electrical field internally to the body structure.

22. The method of claim 14, wherein at least one of the first tissue location and the second tissue location is selected from a group consisting essentially of a heart, a bladder, a stomach, a brain, and at least one limb.

23. The method of claim 14, further comprising:

converting the measurements to a destination device-compatible format; and

conveying the converted measurements to a destination device.

33. The device of claim 14, wherein at least one of the first tissue location and the second tissue location is selected from a group consisting essentially of a heart, a bladder, a stomach, a brain, and at least one limb.

25. A lead device, comprising:

at least one pair of sensors capable of association with a respective first tissue location and a respective second tissue location; and

a logic module to;

for each pair of sensors in the at least one pair of sensors;

determine at a first point in time a first impedance measurement associated with a first frequency between the at least one pair of sensors;

determine at a second point in time a second impedance measurement associated with a second frequency between the at least one pair of sensors; and

compare a ratio of the first impedance measurement to the second impedance measurement to determine a volume-related value associated with an area located between the first tissue location and the second tissue location.

26. The device of claim 25, wherein the area comprises at least one of a solid tissue and a fluid tissue.

27. The device of claim 26, wherein the fluid tissue comprises at least one of a blood tissue and a non-blood tissue.

28. The device of claim 25, wherein the area forms an empty chamber between the first tissue location and the second tissue location.

29. The device of claim 25, wherein the logic module is characterized in that it will:

determine, over a first time interval, a first sequence of impedance measurements associated with a first frequency;

determine, over a second time interval, a second sequence of impedance measurements associated with a second frequency; and

compare ratios of measurements of the first sequence to corresponding measurements of the second sequence to determine volume-related data and frequency data associated with an area located between the first tissue location and the second tissue location.

30. The device of claim 29, further comprises:

a ratio comparison module to compare each ratio of measurements associated with a each pair of sensors in the at least one pair of sensors to determine to determine volume-related data and frequency data associated with all the pairs of sensors in the at least one pair of sensors.

31. The device of claim 25, further comprising:

a field module to generate an electrical field of alternating current.

32. The device of claim 31, wherein the field module applies the electrical field of alternating current in at least one of the following manners:

externally to the body structure;

internally to the body structure; and

externally and internally to the body structure.

34. A system comprising:

a lead device, having at least one pair of sensors capable of association with a respective first tissue location and a respective second tissue location;

a logic module to;

for each pair of sensors in the at least one pair of sensors;

determine at a first point in time a first impedance measurement associated with a first frequency between the at least one pair of sensors;

determine at a second point in time a second impedance measurement associated with a second frequency between the at least one pair of sensors; and

compare a ratio of the first impedance measurement to the second impedance measurement to determine a volume-related value associated with an area located between the first tissue location and the second tissue location; and

a communication module to convert the measurements to a destination device-compatible format and to communicate the converted measurements to a destination device.

35. The system of claim 34, further comprising the destination device.

36. The system of claim 35, wherein the destination device further comprises a can.

37. The system of claim 34, further comprising a delivery element to generate an electrical field.