METHOD OF COUNTERACTING SEIZURES
First Claim
1. A device for counteracting seizure events in a mammalian brain, the device comprising:
- at least one electrode configured to apply an electrical stimulus to the brain; and
a stimulus generator which is arranged to apply an electrical stimulation to the brain via the at least one electrode, the electrical stimulation being pulsatile and comprising pulses forming a pulse train, wherein the pulse train has an inconstant inter pulse interval such that the pulse rate is not constant throughout the pulse train, and wherein the pulses having a pulse width greater than substantially 300 μ
sec.
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Abstract
The present invention provides a method for counteracting seizure events in a mammalian brain, the method comprising applying an electrical stimulus to the brain, the electrical stimulus being pulsatile and comprising pulses forming a pulse train. In order to effectively “desynchronize” the neural activity patterns in the brain, the pulse train can be at a frequency greater than substantially 300 Hz and at a duty cycle greater than substantially 20%, the pulse train can have an inconstant inter pulse interval such that the pulse rate is not constant throughout the pulse train, and the pulses can have a pulse width greater than substantially 300 μsec. Apparatus for carrying out the method is also described.
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Citations
66 Claims
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1. A device for counteracting seizure events in a mammalian brain, the device comprising:
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at least one electrode configured to apply an electrical stimulus to the brain; and a stimulus generator which is arranged to apply an electrical stimulation to the brain via the at least one electrode, the electrical stimulation being pulsatile and comprising pulses forming a pulse train, wherein the pulse train has an inconstant inter pulse interval such that the pulse rate is not constant throughout the pulse train, and wherein the pulses having a pulse width greater than substantially 300 μ
sec. - View Dependent Claims (2, 3, 5, 6, 8, 11, 13, 14, 15, 16, 17, 18, 19)
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4. (canceled)
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7. (canceled)
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9-10. -10. (canceled)
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12. (canceled)
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20. A device for counteracting seizure events in a mammalian brain, the device comprising:
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at least one electrode configured to apply an electrical stimulus to the brain; and a stimulus generator which is arranged to apply an electrical stimulation to the brain via the at least one electrode, the electrical stimulation being pulsatile and comprising pulses forming a pulse train having a frequency greater than substantially 300 Hz and at a duty cycle greater than substantially 20%. - View Dependent Claims (21, 22, 23, 24, 32, 33)
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25-31. -31. (canceled)
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34-35. -35. (canceled)
- 36. A method for counteracting seizure events in a mammalian brain, the method comprising applying an electrical stimulus to the brain, the electrical stimulus being pulsatile and comprising pulses forming a pulse train, wherein the pulse train has an inconstant inter pulse interval such that the pulse rate is not constant throughout the pulse train, and wherein the pulses having a pulse width greater than substantially 300 μ
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40. (canceled)
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42. (canceled)
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44-45. -45. (canceled)
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47. (canceled)
- 52. A method for counteracting seizure events in a mammalian brain, the method comprising applying an electrical stimulus to the brain, the electrical stimulus being pulsatile and comprising pulses forming a pulse train at a frequency greater than substantially 300 Hz and at a duty cycle greater than substantially 20%.
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57-63. -63. (canceled)
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66-67. -67. (canceled)
Specification