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METHODS AND DEVICES FOR MOLECULAR ASSOCIATION AND IMAGING

  • US 20120108459A1
  • Filed: 10/23/2011
  • Published: 05/03/2012
  • Est. Priority Date: 10/10/2007
  • Status: Abandoned Application
First Claim
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1. A method for diagnostic molecular association of a sample comprising:

  • disposing a fluid containing a sample for molecular association between a first and second substrate, said first substrate having an array of spots comprising biological material coupled to the substrate and said second substrate separated from the first substrate by a predetermined distance, said fluid occupying a chamber defined by said first and second substrates;

    applying energy to said first substrate with a plurality of temperature affecting devices coupled to said first substrate, each of said temperature affecting devices sources providing at least one adjustable temperature to said first substrate and being disposed to create a temperature gradient profile along a surface of said first substrate; and

    orienting said temperature gradient profile substantially along a gravitational field to generate Rayleigh-Benard instabilities;

    whereby said temperature gradient profile enhances molecular association between molecules in said sample and a particular biological material coupled to said first substrate.

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