COMPOSITIONS FOR CONFERRING TOLERANCE TO VIRAL DISEASE IN SOCIAL INSECTS, AND THE USE THEREOF
First Claim
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1. A bee-ingestible composition comprising an isolated dsRNA comprising an RNA sequence complementary to a bee pathogen specific mRNA and bee feed, wherein said dsRNA downregulates expression of said bee pathogen specific mRNA.
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Abstract
Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
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24 Claims
- 1. A bee-ingestible composition comprising an isolated dsRNA comprising an RNA sequence complementary to a bee pathogen specific mRNA and bee feed, wherein said dsRNA downregulates expression of said bee pathogen specific mRNA.
- 13. A nucleic acid agent comprising a nucleic acid sequence encoding an RNA sequence complementary to the nucleic acid sequence as set forth in SEQ ID NO:
Specification