GASTRIC BANDING SYSTEM ADJUSTMENT BASED ON A SATIETY AGENT CONCENTRATION LEVEL

• US 20120108921A1
• Filed: 11/03/2010
• Published: 05/03/2012
• Est. Priority Date: 11/03/2010
• Status: Abandoned Application

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Van Epps, Dennis, Raven, Joseph
• Application Number:
  US12/938,755
• Publication Number:
  US 20120108921A1
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61F 5/0046 with wireless means
• CPC Class Codes: A61F 5/0053 remotely adjustable
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

Methods and devices are provided for adjusting a gastric band to obtain a predetermined optimal expression of hormones. These hormones may be used to control appetite, metabolism and other weight control mechanisms. Ultimately, weight-loss efficacy is desired by tightening or loosening the gastric band based on hormone response.

Claims

1. A method of determining whether a patient is at or near optimal satiety-inducing agent concentration levels following a gastric band adjustment comprising:

collecting a bodily fluid sample from the patient in response to waiting a predetermined amount of time after the gastric band adjustment;

detecting a concentration level of one or more satiety-inducing agents from the bodily fluid sample; and

comparing the detected concentration levels of the one or more satiety-inducing agents with a predetermined range for each of the one or more satiety-inducing agents.

2. The method of claim 1, wherein the satiety-inducing agent is a hormone.

3. The method of claim 1, wherein the bodily fluid is blood.

4. The method of claim 2, wherein the hormone is one of:

a peptide hormone and a brain-gut satiety hormone.

5. A method of determining whether a patient is at or near an optimal satiety-inducing agent concentration level, comprising:

collecting a first bodily fluid sample from the patient;

adjusting a gastric band;

collecting a second bodily fluid sample from the patient after adjusting the gastric band;

for at least one satiety-inducing agent, determining a difference between a satiety-inducing agent concentration level of the first bodily fluid sample and a satiety-inducing agent concentration level of the second bodily fluid sample; and

for each satiety-inducing agent concentration level difference determined, comparing the difference with a predetermined range.

6. The method of claim 5, further comprising:

performing one of tightening or loosening the gastric band in response to determining that at least one satiety-inducing agent concentration level difference is not within the predetermined range.

7. The method of claim 5, wherein the satiety-inducing agent is a hormone.

8. The method of claim 5, wherein the bodily fluid is blood.

9. A device fully insertable into a human body, configured to determine a concentration level of one or more satiety-inducing agents in plasma, the device comprising:

a processor;

a memory coupled to the processor and located within the body, the memory storing instructions, that when executed cause the device to;

collect a bodily fluid sample from the human body;

detect a concentration level of one or more satiety-inducing agents from the plasma; and

compare the detected concentration levels of the one or more satiety-inducing agents with a predetermined range for each of the one or more satiety-inducing agents.

10. The device of claim 9, wherein the memory further stores instructions that when executed, cause the device to:

transmit to a receiver, the result of comparing the detected concentration levels of the one or more satiety-inducing agents with a predetermined range for each of the one or more satiety-inducing agents.

11. The device of claim 9, wherein the satiety-inducing agent in is a hormone.

12. A device for determining a concentration level of one or more satiety-inducing agents in plasma, the device comprising:

a device body configured to be fully insertable into a human body;

a sensor connectable to the device body, configured to detect a concentration level of one or more satiety-inducing agents from plasma within the human body;

a storage configured to store a predetermined range corresponding to each of the one or more satiety-inducing agents;

a comparator configured to compare the concentration level of the one or more satiety-inducing agents detected by the sensor to the predetermined range corresponding to each of the one or more satiety-inducing agents; and

a transceiver configured to communicate the output of the comparator to a receiver.

13. The device of claim 12, wherein each of the satiety-inducing agents is a different hormone.

14. A device fully insertable into a human body, configured to determine a concentration level of one or more satiety-inducing agents in plasma and further configured to communicate with a gastric band attached to the human body, the device comprising:

a processor;

a memory coupled to the processor and located within the body, the memory storing instructions, that when executed cause the device to;

detect a concentration level of one or more satiety-inducing agents from the plasma;

determine that the concentration levels of the one or more satiety-inducing agents detected from the plasma is outside a predetermined range; and

transmit a command to adjust a constriction level of a gastric band in response to determining that the concentration levels of the one or more satiety-inducing agents detected from the plasma is outside the predetermined range.

15. The device of claim 14, wherein each of the one or more satiety-inducing agents is a hormone.

16. The device of claim 14, wherein in response to the command to adjust the constriction level of the gastric band, the concentration level of at least one satiety-inducing agent increases or decreases acutely.

17. The device of claim 14, wherein in response to the command to adjust the constriction level of the gastric band, the concentration level of at least one satiety-inducing agent increases or decreases in accordance with a bimodal model.

18. The device of claim 14, wherein in response to the command to adjust the constriction level of the gastric band, the concentration level of at least one satiety-inducing agent increases or decreases in accordance with a polimodal model.

19. The device of claim 14, wherein in response to the command to adjust the constriction level of the gastric band, the concentration level of at least one satiety-inducing agent increases or decreases in accordance with a uni-modal model.

20. The device of claim 14, wherein in response to the command to adjust the constriction level of the gastric band, the concentration level of at least one satiety-inducing agent increases or decreases in accordance with a logrithmic model.

21. A method for determining an optimal amount of constriction applied by a gastric band implanted around a stomach of an obese patient, the method comprising the steps of:

laparoscopically implanting the gastric band around the stomach of an obese patient;

collecting a blood, serum or plasma sample from the obese patient;

detecting a concentration level of one or more satiety-inducing agents in the sample; and

if the concentration level is higher than optimal, adjusting the gastric band so that it applies a lesser constriction to the stomach, and

if the concentration level is lower than optimal, adjusting the gastric band so that it applies a greater constriction to the stomach.