DRUG DELIVERY SYSTEM FOR ACCELERATED SUBCUTANEOUS ABSORPTION
First Claim
1. A drug delivery method, comprising:
- a) dissolving a first drug at a substantially non-toxic concentration with a fluid solvent, wherein the first drug is operative to produce local capillary vasodilatation or to produce increased bulk flow of fluid by depolymerization of hyaluronic acid; and
b) subcutaneously or intramuscularly applying the fluid containing the first drug to a patient.
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Abstract
A method for accelerating subcutaneous absorption of a fluid or drug into the systemic circulation of a specific targeted tissue. A first drug operative to produce local capillary vasodilatation and/or increase the rate of bulk flow of solution through the interstitial space is mixed with a fluid. The fluid may contain a crystalloid solution or a dilute solution of a pharmacologic drug required for a routine or emergency therapeutic treatment for a patient. The first drug is substantially non-toxic to the patient. The fluid mixed with the first drug is then delivered subcutaneously or into deeper tissues of the patient, by use of a hyperdermic needle or infiltration cannula. As the capillaries are dilated, the fluid is efficiently absorbed and circulated systemically.
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Citations
18 Claims
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1. A drug delivery method, comprising:
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a) dissolving a first drug at a substantially non-toxic concentration with a fluid solvent, wherein the first drug is operative to produce local capillary vasodilatation or to produce increased bulk flow of fluid by depolymerization of hyaluronic acid; and b) subcutaneously or intramuscularly applying the fluid containing the first drug to a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of increasing absorption rate of a therapeutic drug, comprising:
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applying a first solution in a first level under skin of a patient, wherein the first solution contains a therapeutic drug for treating subcutaneous tissue of the patient; and applying a second solution in a second level under the skin of the patient, wherein the second solution contains a vasoconstrictive drug;
whereinthe second level is deeper than the first level to serve as a buffer for preventing or delaying absorption of the therapeutic drug into deep vascular tissue. - View Dependent Claims (13, 14, 15)
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16. A method of increasing absorption rate of a therapeutic drug, comprising:
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applying a first solution in a first level under the skin of a patient, wherein the first solution contains a therapeutic drug for treating the skin of the patient; and applying a second solution in a second level under the skin of the patient, wherein the second solution contains a vasoconstrictive drug only;
whereinthe first level is deeper than the second level to serve as a buffer for preventing or delaying absorption of the therapeutic drug into superficial region of the skin. - View Dependent Claims (17, 18)
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Specification