Multi-Electrode Neurostimulation Device

• US 20120109262A1
• Filed: 10/31/2011
• Published: 05/03/2012
• Est. Priority Date: 10/29/2010
• Status: Active Grant

• Current Assignee: Medtronic Bakken Research Center B.V. (Medtronic Plc)
• Original Assignee: Sapiens Steering Brain Stimulation B.V. (Medtronic Plc)
• Inventors: Martens, Hubert Cécile François
• Granted Patent: US 9,020,604 B2
• Time in Patent Office: Days
• US Class Current: 607/62
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/3616 Voltage density or current density
• CPC Class Codes: A61N 1/36182 Direction of the electrical field, e.g. with sleeve around stimulating electrode
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

A neurostimulation device is provided comprising an input, a neurostimulation probe, a stimulation unit and a distribution calculation module. At the input stimulation data is received comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle. The neurostimulation probe comprises an array of stimulation electrodes which are coupled to the stimulation unit. The stimulation unit, in accordance with a specified current distribution, provides currents to the respective stimulation electrodes for generating an electric field gradient. The distribution calculation module is coupled to the input and the stimulation unit for based on the stimulation data determining a preferred position and orientation for the electric field gradient, and based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.

Claims

1. A neurostimulation device comprising:

an input for receiving stimulation data comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle;

a neurostimulation probe with an array of stimulation electrodes;

a stimulation unit coupled to the stimulation electrodes for, in accordance with a specified current distribution, providing currents to the respective stimulation electrodes for generating an electric field gradient; and

a distribution calculation module coupled to the input and the stimulation unit for;

based on the stimulation data determining a preferred position and orientation for the electric field gradient, and

based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.

2. A neurostimulation device as claimed in claim 1, wherein the distribution calculation module is operative to calculate the specified current distribution such that the electric field gradient is substantially parallel to at least one fiber bundle with a high stimulation preferability.

3. A neurostimulation device as claimed in claim 1, wherein the distribution calculation module is operative to calculate the specified current distribution such that the electric field gradient is substantially perpendicular to at least one fiber bundle with a low stimulation preferability.

4. A neurostimulation device as claimed in claim 1, wherein the distribution calculation module is operative to calculate the specified current distribution as a tripolar stimulation profile.

5. A neurostimulation device as claimed in claim 1, wherein the stimulation data further comprises information relating to fiber bundle diameter variations over a length of the at least one fiber bundle and wherein the distribution calculation module is operative to calculate the specified current distribution such that the electric field gradient is larger where the fiber bundle diameter of the at least one fiber bundle is small relative to other parts of the at least one fiber bundle.

6. A neurostimulation device as claimed in claim 1, wherein the stimulation data further comprises information relating to fiber orientation variations over a length of the at least one fiber bundle.

7. A method of calculating a specified current distribution for an array of stimulation electrodes of a neurostimulation device, the method comprising the steps of:

receiving stimulation data comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle;

based on the stimulation data determining a preferred position and orientation for an electric field gradient to be generated by the array of stimulation electrodes; and

based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.

8. A method of calculating a specified current distribution according to claim 7, further comprising a step of providing currents to the respective stimulation electrodes, in accordance with the specified current distribution.

9. A computer program product for calculating a specified current distribution, which program is operative to cause a processor to perform the method as claimed in claim 7.