SWELLABLE BIODEGRADABLE POLYMERIC MATRICES AND METHODS
First Claim
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1. A biocompatible biodegradable swellable or swollen polymeric matrix comprising first and second polymer-containing segments crosslinked via polymerized groups, wherein the first polymer-containing segment comprises poly-α
- (1→
4)glucopyranoseand the second polymer-containing segment comprises a biocompatible biostable hydrophilic polymer.
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Abstract
The invention provides biodegradable polymeric hydrogel matrices having excellent durability and swellability. The matrices are formed from a combination of poly-α(1→4)glucopyranose macromer and a biocompatible biostable hydrophilic macromer. The matrices can be used in association with a medical device or alone. In some methods the polymeric matrix is placed or formed at a target site in which the matrix swells and occludes the target area, and is able to be degraded at the target site after period of time.
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Citations
29 Claims
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1. A biocompatible biodegradable swellable or swollen polymeric matrix comprising first and second polymer-containing segments crosslinked via polymerized groups, wherein the first polymer-containing segment comprises poly-α
- (1→
4)glucopyranoseand the second polymer-containing segment comprises a biocompatible biostable hydrophilic polymer. - View Dependent Claims (2, 4, 5, 7, 9, 10, 12, 14, 15, 16, 17, 18, 27, 28)
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3. (canceled)
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6. (canceled)
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8. (canceled)
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11. (canceled)
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13. (canceled)
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19. (canceled)
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20. (canceled)
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21. A method for forming a biocompatible biodegradable swellable or swollen polymeric matrix comprising steps of:
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(a) providing a composition comprising (i) poly-α
(1→
4)glucopyranose comprising pendent polymerizable groups, and(ii) a biocompatible biostable hydrophilic polymer comprising a pendent polymerizable group, and (b) activating the polymerizable groups to cause crosslinking of the poly-α
(1→
4)glucopyranose and biocompatible biostable hydrophilic polymer and matrix formation. - View Dependent Claims (22, 24, 26, 29)
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23. (canceled)
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25. (canceled)
Specification