METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES
First Claim
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1. A method for the solid-phase based production of a compound of the general formula (I):
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Abstract
The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.
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20 Claims
- 1. A method for the solid-phase based production of a compound of the general formula (I):
- 16. A compound of the general formula (IIIa)
- 17. The compound of the general formula (IIIb)
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