RESPIRATORY INDUCTION APPARATUS, RESPIRATORY INDUCTION PROGRAM, AND PARTICLE BEAM THERAPY SYSTEM

• US 20120119115A1
• Filed: 11/16/2010
• Published: 05/17/2012
• Est. Priority Date: 11/16/2010
• Status: Active Grant

• Current Assignee: Mitsubishi Electric Corporation
• Original Assignee: Mitsubishi Electric Corporation
• Inventors: Iwata, Takaaki
• Granted Patent: US 8,808,341 B2
• Time in Patent Office: Days
• US Class Current: 250/492.3
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1068 Gating the beam as a function of a physiological signal
• CPC Class Codes: A61N 5/1079 Sharing a beam by multiple treatment stations
• CPC Class Codes: G21K 5/00 Irradiation devices discharge tubes for irradiating H01J37/00

Abstract

The objective is to obtain a respiratory induction apparatus and a particle beam therapy system in which respiration can appropriately be induced by accurately evaluating the respiration. There are provided a respiratory induction control unit (7cC) that generates a desired respiratory signal (R_tj(t)) for respiratory induction; a real respiration measurement unit (7a) that outputs a real respiratory signal (R_rl(t)) obtained by measuring real respiration of a patient; and a respiration evaluation unit (7cE) in which by, as a unit, utilizing data of a single period (T_res) of the desired respiratory signal (R_tj(t)), there is calculated a pair of coefficients (a₁ and b₁), of trigonometric functions, which correspond to the 1st-order terms by means of Fourier series expansion of data of the desired respiratory signal (R_tj(t)) and data of the real respiratory signal (R_rl(t)), which is acquired in synchronization with the data of the desired respiratory signal (R_tj(t)), and there are performed comparisons between the respective gains (G_tj and G_rl) and between the respective phases (φ_tj and φ_rl), which are obtained from the coefficients (a₁ and b₁), so that there is evaluated a misalignment of the real respiration from the desired respiratory signal.

Claims

1. A respiratory induction apparatus for inducing respiration of a patient in particle beam therapy, comprising:

a desired respiratory signal generating unit that generates a desired respiratory signal for inducing respiration of the patient;

a real respiration measurement unit that measures real respiration of the patient and outputs a real respiratory signal obtained through the measurement;

a respiration evaluation unit in which by, as a calculation unit, utilizing data of a single period of the desired respiratory signal, there is calculated a pair of coefficients, of trigonometric functions, which correspond to the 1st-order terms by means of Fourier series expansion of the desired respiratory signal and the real respiratory signal, which is acquired in synchronization with the desired respiratory signal, and there are performed comparisons between the respective gains and between the respective phases, which are obtained from the calculated coefficients, so that there is evaluated a misalignment of the real respiration from the desired respiratory signal; and

a modification information generating unit that generates modification information to modify the misalignment of the real respiration, based on the evaluation results by the respiration evaluation unit.

2. The respiratory induction apparatus according to claim 1, wherein the respiration evaluation unit determines the state of the real respiration, based on the changing rate of a difference between the respective phases of the desired respiratory signal and the real respiratory signal and/or changing rate of ratio between the respective gains of real respiratory signal and desired respiratory signal.

3. The respiratory induction apparatus according to claim 1, wherein when the respiration evaluation unit determines that a difference between the respective phases of desired respiratory signal and real respiratory signal has maintained a constant value for a predetermined time, the modification information generating unit generates the modification information so that the desired respiratory signal generating unit generates a desired respiratory signal whose phase is shifted by the constant value.

4. The respiratory induction apparatus according to claim 1, wherein the respiration evaluation unit calculates an error between the desired respiratory signal and the real respiratory signal in a predetermined time, and evaluates the misalignment of the real respiration from the desired respiratory signal, including the calculated error.

5. The respiratory induction apparatus according to claim 1, further including a respiration gate signal transformation unit for transforming the desired respiratory signal and the real respiratory signal into respective respiration gate signals suggesting whether or not the desired respiratory signal and the real respiratory signal are smaller than a predetermined threshold value, wherein the respiration evaluation unit calculates an error between the respective respiration gate signals obtained through the transformation, and evaluates the misalignmnet of the real respiration from the desired respiratory signal, including the calculated error.

6. The respiratory induction apparatus according to claim 1, wherein the respiration evaluation unit defines respective trigonometric functions by utilizing the respective gains and the respective phases calculated from the desired respiratory signal and the real respiratory signal, calculates an error between the respective defined trigonometric functions, and evaluates the misalignment of the real respiration from the desired respiratory signal, including the calculated error.

8. A particle beam therapy system comprising:

an accelerator that generates a particle beam;

a plurality of treatment rooms;

a particle beam transport path that connects the accelerator with each of the plurality of treatment rooms;

a switching device, provided in the transport path, that switches the orbits of a particle beam generated by the accelerator, in such a way that the particle beam is supplied to one of the plurality of treatment rooms;

a respiratory induction apparatus, provided in each of the plurality of treatment rooms, according to claim 1; and

an irradiation apparatus, provided in each of the plurality of treatment rooms, that forms a supplied particle beam into an irradiation field corresponding to an irradiation subject and controls irradiation onto the irradiation subject, in synchronization with at least the desired respiratory signal.

9. The particle beam therapy system according to claim 8, wherein the desired respiratory signal generating unit generates the desired respiratory signal, in synchronization with the operation of the accelerator.

10. The particle beam therapy system according to claim 8, wherein the switching device switches the orbits of a particle beam, based on the misalignment of the real respiration from the desired respiratory signal, evaluated by the respiration evaluation unit in each of the plurality of treatment rooms.

11. A particle beam therapy system comprising:

an accelerator that generates a particle beam;

a plurality of treatment rooms;

a particle beam transport path that connects the accelerator with each of the plurality of treatment rooms;

a switching device, provided in the transport path, that switches the orbits of a particle beam generated by the accelerator, in such a way that the particle beam is supplied to one of the plurality of treatment rooms;

a respiratory induction apparatus, provided in each of the plurality of treatment rooms, according to claim 2; and

an irradiation apparatus, provided in each of the plurality of treatment rooms, that forms a supplied particle beam into an irradiation field corresponding to an irradiation subject and controls irradiation onto the irradiation subject, in synchronization with at least the desired respiratory signal.

12. The particle beam therapy system according to claim 11, wherein the switching device switches the orbits of a particle beam, based on the misalignment of the real respiration from the desired respiratory signal, evaluated by the respiration evaluation unit in each of the plurality of treatment rooms.

13. A particle beam therapy system comprising:

an accelerator that generates a particle beam;

a plurality of treatment rooms;

a particle beam transport path that connects the accelerator with each of the plurality of treatment rooms;

a switching device, provided in the transport path, that switches the orbits of a particle beam generated by the accelerator, in such a way that the particle beam is supplied to one of the plurality of treatment rooms;

a respiratory induction apparatus, provided in each of the plurality of treatment rooms, according to claim 3; and

an irradiation apparatus, provided in each of the plurality of treatment rooms, that forms a supplied particle beam into an irradiation field corresponding to an irradiation subject and controls irradiation onto the irradiation subject, in synchronization with at least the desired respiratory signal.

14. The particle beam therapy system according to claim 13, wherein the switching device switches the orbits of a particle beam, based on the misalignment of the real respiration from the desired respiratory signal, evaluated by the respiration evaluation unit in each of the plurality of treatment rooms.

15. A particle beam therapy system comprising:

an accelerator that generates a particle beam;

a plurality of treatment rooms;

a particle beam transport path that connects the accelerator with each of the plurality of treatment rooms;

a switching device, provided in the transport path, that switches the orbits of a particle beam generated by the accelerator, in such a way that the particle beam is supplied to one of the plurality of treatment rooms;

a respiratory induction apparatus, provided in each of the plurality of treatment rooms, according to claim 4; and

an irradiation apparatus, provided in each of the plurality of treatment rooms, that forms a supplied particle beam into an irradiation field corresponding to an irradiation subject and controls irradiation onto the irradiation subject, in synchronization with at least the desired respiratory signal.

16. The particle beam therapy system according to claim 15, wherein the switching device switches the orbits of a particle beam, based on the misalignment of the real respiration from the desired respiratory signal, evaluated by the respiration evaluation unit in each of the plurality of treatment rooms.

17. A particle beam therapy system comprising:

an accelerator that generates a particle beam;

a plurality of treatment rooms;

a particle beam transport path that connects the accelerator with each of the plurality of treatment rooms;

a switching device, provided in the transport path, that switches the orbits of a particle beam generated by the accelerator, in such a way that the particle beam is supplied to one of the plurality of treatment rooms;

a respiratory induction apparatus, provided in each of the plurality of treatment rooms, according to claim 5; and

an irradiation apparatus, provided in each of the plurality of treatment rooms, that forms a supplied particle beam into an irradiation field corresponding to an irradiation subject and controls irradiation onto the irradiation subject, in synchronization with at least the desired respiratory signal.

18. The particle beam therapy system according to claim 17, wherein the switching device switches the orbits of a particle beam, based on the misalignment of the real respiration from the desired respiratory signal, evaluated by the respiration evaluation unit in each of the plurality of treatment rooms.

19. A particle beam therapy system comprising:

an accelerator that generates a particle beam;

a plurality of treatment rooms;

a particle beam transport path that connects the accelerator with each of the plurality of treatment rooms;

a switching device, provided in the transport path, that switches the orbits of a particle beam generated by the accelerator, in such a way that the particle beam is supplied to one of the plurality of treatment rooms;

a respiratory induction apparatus, provided in each of the plurality of treatment rooms, according to claim 6; and

an irradiation apparatus, provided in each of the plurality of treatment rooms, that forms a supplied particle beam into an irradiation field corresponding to an irradiation subject and controls irradiation onto the irradiation subject, in synchronization with at least the desired respiratory signal.

20. The particle beam therapy system according to claim 19, wherein the switching device switches the orbits of a particle beam, based on the misalignment of the real respiration from the desired respiratory signal, evaluated by the respiration evaluation unit in each of the plurality of treatment rooms.

7. A respiratory induction program for establishing on a computer a respiratory induction apparatus that induces respiration of a patient in particle beam therapy, the respiratory induction program comprising:

a desired respiratory signal generating step in which there is generated a desired respiratory signal for inducing respiration of the patient;

a real respiration measurement step in which real respiration of the patient is measured and a real respiratory signal obtained through the measurement is outputted;

a respiration evaluation step in which by, as a calculation unit, utilizing data of a single period of the desired respiratory signal, there is calculated a pair of coefficients, of trigonometric functions, which correspond to the 1st-order terms by means of Fourier series expansion of the desired respiratory signal and the real respiratory signal, which is acquired in synchronization with the desired respiratory signal, and there are performed comparisons between the respective gains and between the respective phases, which are obtained from the calculated coefficients, so that there is evaluated a misalignment of the real respiration from the desired respiratory signal, and

a modification information generating step in which a modification information to modify the misalignment of the real respiration is generated, based on the evaluation results evaluated in the respiration evaluation step.