DRY WHOLE MILK PREPARATIONS CONTAINING PROBIOTIC MICRO-ORGANISMS

• US 20120121561A1
• Filed: 05/11/2010
• Published: 05/17/2012
• Est. Priority Date: 05/11/2009
• Status: Abandoned Application

• Current Assignee: Nestec SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Mercenier, Annick, Nutten, Sophie, Prioult, Guenolee
• Application Number:
  US13/319,964
• Publication Number:
  US 20120121561A1
• Time in Patent Office: Days
• US Class Current: 424/93.44
• CPC Class Codes: A23K 10/18 of live microorganisms
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2400/113 Acidophilus
• CPC Class Codes: A23V 2400/123 Bulgaricus
• CPC Class Codes: A23V 2400/125 Casei
• CPC Class Codes: A23V 2400/151 Johnsonii
• CPC Class Codes: A23V 2400/165 Paracasei
• CPC Class Codes: A23V 2400/173 Reuteri
• CPC Class Codes: A23V 2400/175 Rhamnosus
• CPC Class Codes: A23V 2400/231 Lactis
• CPC Class Codes: A23V 2400/249 Thermophilus
• CPC Class Codes: A23V 2400/519 Breve
• CPC Class Codes: A23V 2400/531 Lactis
• CPC Class Codes: A23V 2400/533 Longum
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61P 1/00 : Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 : Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/04 : for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/12 : Antidiarrhoeals
• CPC Class Codes: A61P 1/14 : Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 11/00 : Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 : Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/04 : for throat disorders
• CPC Class Codes: A61P 11/06 : Antiasthmatics
• CPC Class Codes: A61P 13/02 : of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 : Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/02 : for disorders of the vagina
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 21/02 : Muscle relaxants, e.g. for tetanus or cramps
• CPC Class Codes: A61P 27/02 : Ophthalmic agents
• CPC Class Codes: A61P 27/16 : Otologicals
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 : Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 : Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/06 : for tuberculosis
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: A61P 31/18 : for HIV
• CPC Class Codes: A61P 31/22 : for herpes viruses
• CPC Class Codes: A61P 33/00 : Antiparasitic agents
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 37/00 : Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 : Immunomodulators
• CPC Class Codes: A61P 37/04 : Immunostimulants
• CPC Class Codes: A61P 37/06 : Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 : Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/04 : Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: C12N 1/005 : after treatment of microbial biomass not covered by C12N1/02 - C12N1/08
• CPC Class Codes: C12N 1/20 : Bacteria; Culture media therefor
• CPC Class Codes: C12N 1/36 : Adaptation or attenuation of cells
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to the field of nutrition for young children. In particular, the present invention relates to dry whole milk preparations comprising probiotic micro-organisms to be administered to young children older than 12 months. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example.

Claims

1. Dry whole milk composition comprising probiotic micro-organisms and a prepiotic selected from the group consisting of pea hull fibre, oligofructose inulin and combinations thereof to be administered young children starting from the age of 12 months.

2. Composition in accordance with claim 1 comprising a protein source in an amount of 20-27 g/100 g dry weight, a carbohydrate source in an amount of 49-52 g/100 g dry weight, and a lipid source in an amount of 19-24 g/100 g dry weight.

3. Composition in accordance with claim 1, comprising linoleic acid and alpha-linoleic acid in a ratio of 10:

1 to 6;

1.

5. Composition in accordance with claim 1, wherein the probiotic micro-organisms comprise non-replicating probiotic micro-organisms.

6. Composition in accordance with claim 1, comprising probiotic micro-organisms in an amount corresponding to about 10⁶ to 10¹² cfu per serving.

7. Composition in accordance claim 5, wherein the non-replicating probiotic micro-organisms were rendered non-replicating by a heat-treatment.

8. Composition in accordance with claim 7, wherein the heat treatment is a high temperature treatment at about 71.5-150°

C. for about 1-120 seconds.

10. Composition in accordance with claim 7, wherein the heat treatment is performed at a temperature of about 70-150°

C. for about 3 minutes-2 hours.

12. Composition in accordance with claim 1, wherein at least 90% of the probiotics are non-replicating.

13. Composition in accordance with claim 1, wherein the probiotic micro-organisms are selected from the group consisting of bifidobacteria, lactobacilli, propionibacteria, and combinations thereof.

14. Composition in accordance with claim 1, wherein the probiotic micro-organisms are selected from the group consisting of Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Bifidobacterium lactis NCC 2818, Lactobacillus johnsonii La1, Lactobacillus paracasei NCC 2461, Lactobacillus rhamnosus NCC 4007, Lactobacillus reuteri DSM17983, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, and combinations thereof.

15. Composition in accordance with claim 1, containing about 0.005 mg-1000 mg of non-replicating micro-organisms per daily dose.

9. A method for the prevention or treatment of inflammatory disorders in a young child starting from the age of 12 months comprising administering a dry whole milk composition comprising probiotic micro-organisms and a prepiotic selected from the group consisting of pea hull fibre, oligofructose inulin and combinations thereof to an individual in need of same.

4. Method in accordance with claim 9, wherein a serving comprising about 30-36 g of the dry composition and 200 to 250 mL water is to be administered once for breakfast and a second time during the day.

16. Method in accordance with claim 9, wherein the composition comprises a protein source in an amount of 20-27 g/100 g dry weight, a carbohydrate source in an amount of 49-52 g/100 g dry weight, and a lipid source in an amount of 19-24 g/100 g dry weight.

17. Method in accordance with claim 9, wherein the probiotic micro-organisms comprise non-replicating probiotic micro-organisms.

18. Method in accordance with claim 9, wherein the probiotic micro-organisms are selected from the group consisting of bifidobacteria, lactobacilli, propionibacteria, and combinations thereof.

19. Method in accordance with claim 9, wherein the probiotic micro-organisms are selected from the group consisting of Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Bifidobacterium lactis NCC 2818, Lactobacillus johnsonii La1, Lactobacillus paracasei NCC 2461, Lactobacillus rhamnosus NCC 4007, Lactobacillus reuteri DSM17983, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, and combinations thereof.

11. A method for the prevention or treatment disorders related to a compromised immune defense in a young child starting from the age of 12 months comprising administering a dry whole milk composition comprising probiotic micro-organisms and a prepiotic selected from the group consisting of pea hull fibre, oligofructose inulin and combinations thereof to an individual in need of same.

20. Method in accordance with claim 11, wherein a serving comprising about 30-36 g of the dry composition and 200 to 250 mL water is to be administered once for breakfast and a second time during the day.

21. Method in accordance with claim 11, wherein the composition comprises a protein source in an amount of 20-27 g/100 g dry weight, a carbohydrate source in an amount of 49-52 g/100 g dry weight, and a lipid source in an amount of 19-24 g/100 g dry weight.

22. Method in accordance with claim 11, wherein the probiotic micro-organisms comprise non-replicating probiotic micro-organisms.

23. Method in accordance with claim 11, wherein the probiotic micro-organisms are selected from the group consisting of bifidobacteria, lactobacilli, propionibacteria, and combinations thereof.

24. Method in accordance with claim 11, wherein the probiotic micro-organisms are selected from the group consisting of Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Bifidobacterium lactis NCC 2818, Lactobacillus johnsonii La1, Lactobacillus paracasei NCC 2461, Lactobacillus rhamnosus NCC 4007, Lactobacillus reuteri DSM17983, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, or combinations thereof.