ALANINYL MAYTANSINOL ANTIBODY CONJUGATES
1 Assignment
0 Petitions
Accused Products
Abstract
Linker-drug intermediates of Formula I are conjugated to antibodies to form antibody-drug conjugates where the drug moiety is an N-methylalaninyl-maytansinoid.
-
- L is
-
- E is
-
- n is 2, 3, 4, 5, or 6; m is 2, 3 or 4; and q is 0 or 1.
-
Citations
25 Claims
- 1. A compound selected from Formula I:
- 10. An antibody-drug conjugate selected from Formula Ia or Ib:
Specification