Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
First Claim
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1. A spin valve detector array useful for the detection of magnetic nanoparticles, the detector array comprising:
- a plurality of detection sites, wherein each of the plurality of detection sites comprise;
a first ferromagnetic layer;
a non-magnetic layer facially contacting the first ferromagnetic layer;
a second ferromagnetic layer facially contacting the non-magnetic layer;
an ultrathin passivation layer facially contacting the second ferromagnetic layer; and
a binding molecule bonded to the passivation layer, wherein the binding molecule is at least one of a nucleic acid, a natural DNA, a synthetic DNA, a natural RNA, a synthetic RNA, a peptide, a protein, an antibody, a lipid, a virus, a polymer, a toxin compound, a pharmaceutical compound, a biohazard compound, or an explosive compound.
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Abstract
Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
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Citations
19 Claims
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1. A spin valve detector array useful for the detection of magnetic nanoparticles, the detector array comprising:
a plurality of detection sites, wherein each of the plurality of detection sites comprise; a first ferromagnetic layer; a non-magnetic layer facially contacting the first ferromagnetic layer; a second ferromagnetic layer facially contacting the non-magnetic layer; an ultrathin passivation layer facially contacting the second ferromagnetic layer; and a binding molecule bonded to the passivation layer, wherein the binding molecule is at least one of a nucleic acid, a natural DNA, a synthetic DNA, a natural RNA, a synthetic RNA, a peptide, a protein, an antibody, a lipid, a virus, a polymer, a toxin compound, a pharmaceutical compound, a biohazard compound, or an explosive compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
Specification