Systems, Methods and Materials for Delivery and Debonding on Demand

• US 20120123220A1
• Filed: 04/27/2010
• Published: 05/17/2012
• Est. Priority Date: 04/27/2009
• Status: Active Grant

• Current Assignee: Avery Dennison Corporation
• Original Assignee: Avery Dennison Corporation
• Inventors: Iyer, Pradeep, Edwards, David N., Mallya, Prakash, Rozenbaoum, Eugene, Ly, Tien
• Granted Patent: US 8,946,499 B2
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/0223 characterized by parametric properties of the fluid retention layer, e.g. absorbency, wicking capacity, liquid distribution
• CPC Class Codes: A61F 13/0246 characterised by the skin-adhering layer
• CPC Class Codes: A61F 13/025 having a special distribution arrangement of the adhesive
• CPC Class Codes: A61F 13/0259 characterised by the release liner covering the skin adhering layer
• CPC Class Codes: A61F 17/00 First-aid kits
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: C09J 2301/18 characterized by perforations in the adhesive tape
• CPC Class Codes: C09J 2301/502 process for debonding adherents
• CPC Class Codes: C09J 7/22 Plastics; Metallised plastics
• CPC Class Codes: Y10T 156/1111 Using solvent during delaminating [e.g., water dissolving adhesive at bonding face during delamination, etc.]
• CPC Class Codes: Y10T 156/1994 Means for delaminating from release surface
• CPC Class Codes: Y10T 428/24314 Slit or elongated
• CPC Class Codes: Y10T 428/24331 including nonapertured component
• CPC Class Codes: Y10T 428/24612 Composite web or sheet
• CPC Class Codes: Y10T 428/24802 Discontinuous or differential coating, impregnation or bond [e.g., artwork, printing, retouched photograph, etc.]
• CPC Class Codes: Y10T 428/2848 Three or more layers

Abstract

Various systems, methods and materials are disclosed that enable efficient delivery of an agent into an adhesively adhered article, in which the agent elicits a desired outcome, on demand. This strategy, though general in scope, is also more specifically described with regard to enabling painless or atraumatic removal of products adhering to mammalian tissues such as skin and hair by suitably exploiting the ingress of an appropriate agent or like fluid. Other techniques and articles that aid in the handling or removal of such adhesive products are also disclosed.

Claims

1. A multilayer laminate that is adherable to a substrate and selectively releasable therefrom upon application of an agent to an outer face or perimeter of the laminate and appropriate contacting between the agent and the adhesive, the laminate comprising:

an interior layer defining a plurality of fluid passageway conduits or apertures extending through the interior layer, the interior layer exhibiting a controllable flow profile across the thickness of the interior layer, the interior layer defining a bottom surface and an oppositely directed top surface;

an adhesive layer disposed along the bottom surface of the interior layer;

a carrier layer is disposed on the top surface of the interior layer;

wherein upon contacting the adhesive layer to the substrate, the laminate is adhesively adhered thereto;

upon removal of the cover layer from the laminate, the interior layer and plurality of fluid passageway conduits are exposed; and

upon application of an effective amount of the agent to the top surface of the interior layer, transport of the agent to the adhesive, and passage of sufficient contact time between the agent and the adhesive, the adhesively adhered laminate can be easily removed from the substrate.

2. The multilayer laminate of claim 1 wherein the adhesive of the laminate has a tackiness that decreases after the agent is applied.

3. The multilayer laminate of claim 1, wherein the conduits defined in the interior layer have diameters that range from about 0.5 mils to about 2000 mils.

4. The multilayer laminate of claim 1, wherein the conduits have diameters that range from about 1 mil to about 400 mils

5. The multilayer laminate of claim 1, wherein the conduits have diameters that range from about 10 mils to about 300 mils.

6. The multilayer laminate of claim 1, wherein the interior layer includes a plurality of apertures, perforations, slits, pores or combinations thereof that enable controlled passage of one or more agents from one face of the layer through another face of the layer.

7. The multilayer laminate of claim 1, wherein the agent is an adhesive deactivating agent.

8. The multilayer laminate of claim 7, wherein the adhesive deactivating agent is selected from the group consisting of silicones, perfluoroalkyl derivatives, low molecular weight oils, aqueous compositions, alkyl esters, limonene derivatives, paraffin solvents, hydrocarbon solvents, alkyl ethers, aromatic esters, surfactants, and combinations thereof.

9. The multilayer laminate of claim 1, wherein the number of conduits or apertures range from about 5 to about 500 per square inch of layer.

10. The multilayer laminate of claim 1, wherein the number of conduits or apertures range from about 10 to about 250 per square inch of layer.

11. The multilayer laminate of claim 1, wherein the agent includes a medicant-like anesthetic, analgesic, cooling/heating agent or combination thereof.

12. The multilayer laminate of claim 1, wherein the agent is applied via a secondary carrier device.

13. The multilayer laminate of claim 1, wherein the agent is applied via a skin barrier-like application.

14. The multilayer laminate of claim 1, wherein the agent is applied via an individually sterile packed dispenser or spray.

15. The multilayer laminate of claim 1, wherein the agent is applied via an impregnated gauze/foam carrier.

16. The multilayer laminate of claim 1, wherein the agent is applied via an encapsulated release on demand medium to measure out needed amounts.

17. The multilayer laminate of claim 1, wherein the adhesive layer includes a pressure sensitive adhesive.

18. The multilayer laminate of claim 17, wherein the pressure sensitive adhesive is non-pervious to fluid flow.

19. The multilayer laminate of claim 17, wherein the pressure sensitive adhesive is pervious to fluid flow.

20. The multilayer laminate of claim 1, wherein the adhesive layer includes channels incorporated in the adhesive layer of the multilayer laminate which allow for rapid ingress of an adhesive deactivating agent.

21. The multilayer laminate of claim 1, wherein the agent includes a component for coating hair to eliminate hair pull induced pain during removal of the laminate.

22. The multilayer laminate of claim 1, wherein the adhesive layer comprises a pattern of adhesive.

23. The multilayer laminate of claim 1, wherein the laminate further comprises a sensor incorporated into the laminate to provide information as to the state of a wound or other affected area.

24. The multilayer laminate of claim 1, wherein the interior layer is in the form of an infraction layer.

25. The multilayer laminate of claim 1, wherein the interior layer includes a region of ink conduits for facilitating fluid flow through the interior layer.

26. The multilayer laminate of claim 25, wherein the ink conduits include a pattern defining a plurality of continuous flow channels.

27. The multilayer laminate of claim 25, wherein the ink conduits include a pattern defining a plurality of discontinuous flow channels.

28. A system for selectively adhering and selectively releasing a multilayer laminate to and from a substrate, the system comprising:

a multilayer laminate comprising (i) an interior layer defining a plurality of fluid passageway conduits or apertures extending through the interior layer, the interior layer exhibiting a controllable flow profile across the thickness of the interior layer, the interior layer defining a bottom face and an oppositely directed top face, (ii) an adhesive layer disposed along the bottom face of the interior layer, and (iii) a cover layer disposed on the top face of the interior layer;

an adhesive deactivating agent;

wherein upon contacting the adhesive layer to the substrate, the laminate is adhesively adhered thereto;

upon removal of the cover layer from the laminate, the interior layer and plurality of fluid passageway conduits are exposed; and

upon application of an effective amount of the adhesive deactivating agent to the top face of the interior layer and passage of sufficient contact time between the adhesive deactivating agent and the adhesive, the adhesively adhered laminate can be easily removed from the substrate.

29. The system of claim 28, wherein the adhesive of the laminate has a tackiness that decreases after the adhesive deactivating agent is applied.

30. The system of claim 28, wherein the conduits defined in the interior layer have diameters that range from about 0.5 mils to about 2000 mils.

31. The system of claim 28, wherein the conduits have diameters that range from about 1 mil to about 400 mils

32. The system of claim 28, wherein the conduits have diameters that range from about 10 mils to about 300 mils.

33. The system of claim 28, wherein the laminate is incorporated in a medical product selected from the group consisting of bandages, dressings, gauze, tape, wound closure covers, closure strips, and pads.

34. The system of claim 28, wherein the interior layer includes a plurality of apertures, perforations, slits, pores or combinations thereof that enable controlled passage of one or more agents from one face of the layer through another face of the layer.

35. The system of claim 28, wherein the adhesive deactivating agent is selected from the group consisting of silicones, perfluoroalkyl derivatives, low molecular weight oils, aqueous compositions, alkyl esters, limonene derivatives, paraffin solvents, hydrocarbon solvents, alkyl ethers, aromatic esters, surfactants, and combinations thereof.

36. The system of claim 28, wherein the number of conduits or apertures range from about 5 to about 500 per square inch of layer.

37. The system of claim 28, wherein the number of conduits or apertures range from about 10 to about 250 per square inch of layer.

38. The system of claim 28, wherein the adhesive deactivating agent includes a medicant-like anesthetic, analgesic, cooling/heating agent or combination thereof.

39. The system of claim 28, wherein the adhesive deactivating agent is applied via a secondary carrier device.

40. The system of claim 28, wherein the adhesive deactivating agent is applied via a skin barrier-like application.

41. The system of claim 28, wherein the adhesive deactivating agent is applied via an individually sterile packed dispenser or spray.

42. The system of claim 28, wherein the adhesive deactivating agent is applied via an impregnated gauze/foam carrier.

43. The system of claim 28, wherein the adhesive deactivating agent is applied via an encapsulated release on demand medium to measure out needed amounts.

44. The system of claim 28, wherein the adhesive layer includes a pressure sensitive adhesive.

45. The system of claim 44, wherein the pressure sensitive adhesive is non-pervious to fluid flow.

46. The system of claim 44, wherein the pressure sensitive adhesive is pervious to fluid flow.

47. The system of claim 28, wherein the adhesive layer includes channels incorporated in the adhesive layer of the multilayer laminate which allows for rapid ingress of the adhesive deactivating agent.

48. The system of claim 28, wherein the adhesive deactivating agent includes a component for coating hair to eliminate hair pull induced pain during pulling off.

49. The system of claim 28, wherein the adhesive layer comprises a pattern of adhesive.

50. The system of claim 28, wherein the multilayer laminate further comprises a sensor incorporated into the laminate to provide information as to the state of a wound or other affected area.

51. The system of claim 28, wherein the adhesive deactivating agent is in the form of a spray, wipe, sterile pad or combinations thereof.

52. The system of claim 28, wherein the interior layer is in the form of an infraction layer.

53. The system of claim 28, wherein the interior layer includes a region of ink conduits for facilitating fluid flow through the interior layer.

54. The system of claim 53, wherein the ink conduits include a pattern defining a plurality of continuous flow channels.

55. The system of claim 53, wherein the ink conduits include a pattern defining a plurality of discontinuous flow channels.

56. A method for selectively adhering a multilayer laminate to and from a substrate, the method comprising the steps of:

providing a multilayer laminate comprising (i) an interior layer defining a plurality of fluid passageway conduits or apertures extending through the interior layer, the interior layer exhibiting a controllable flow profile across the thickness of the interior layer, the interior layer defining a bottom surface and an oppositely directed top surface;

(ii) an adhesive layer disposed along the bottom surface of the interior layer;

(iii) a carrier layer disposed on the top surface of the interior layer; and

(iv) a release liner in contact with the adhesive layer;

removing the release liner from the adhesive layer of the multilayer laminate to thereby expose the adhesive layer;

applying the multilayer laminate onto the substrate;

removing the carrier layer to thereby expose the interior layer;

applying an effective amount of an adhesive deactivating agent onto the interior layer, whereby the agent travels through the interior layer and after sufficient contact time between the agent and the adhesive, the laminate can be easily removed from the substrate.

57. The method of claim 56, wherein the multilayer laminate also comprises (v) an outer cover layer disposed adjacent the carrier layer.

58. The method of claim 56, wherein the adhesive of the laminate has a tackiness that decreases after the adhesive deactivating agent is applied.

59. The method of claim 56, wherein the conduits defined in the interior layer of the laminate have diameters that range from about 0.5 mils to about 2000 mils.

60. The method of claim 56, wherein the conduits have diameters that range from about 1 mil to about 400 mils.

61. The method of claim 56, wherein the conduits have diameters that range from about 10 mils to about 300 mils.

62. The method of claim 56, wherein the interior layer of the laminate includes a plurality of apertures, perforations, slits, pores or combinations thereof that enable controlled passage of one or more agents from one face of the layer through another face of the layer.

63. The method of claim 56, wherein the adhesive deactivating agent is selected from the group consisting of silicones, perfluoroalkyl derivatives, low molecular weight oils, aqueous compositions, alkyl esters, limonene derivatives, paraffin solvents, hydrocarbon solvents, alkyl ethers, aromatic esters, surfactants, and combinations thereof.

64. The method of claim 56, wherein the number of conduits or apertures in, the interior layer of the laminate range from about 5 to about 500 per square inch of layer.

65. The method of claim 56, wherein the number of conduits or apertures in the interior layer of the laminate range from about 10 to about 250 per square inch of layer.

66. The method of claim 56, wherein the adhesive deactivating agent includes a medicant-like anesthetic, analgesic, cooling/heating agent or combination thereof.

67. The method of claim 56, wherein the adhesive deactivating agent is applied via a secondary carrier device.

68. The method of claim 56, wherein the adhesive deactivating agent is applied via a skin barrier-like application.

69. The method of claim 56, wherein the adhesive deactivating agent is applied via an individually sterile packed dispenser or spray.

70. The method of claim 56, wherein the adhesive deactivating agent is applied via an impregnated gauze/foam carrier.

71. The method of claim 56, wherein the adhesive deactivating agent is applied via an encapsulated release on demand medium to measure out needed amounts.

72. The method of claim 56, wherein the adhesive layer includes a pressure sensitive adhesive.

73. The method of claim 72, wherein the pressure sensitive adhesive is non-pervious to fluid flow.

74. The method of claim 72, wherein the pressure sensitive adhesive is pervious to fluid flow.

75. The method of claim 56, wherein the adhesive layer includes channels incorporated in the adhesive layer of the multilayer laminate which allows for rapid ingress of the adhesive deactivating agent.

76. The method of claim 56, wherein the adhesive deactivating agent includes a component for coating hair to eliminate hair pull induced pain during pulling off of the laminate.

77. The method of claim 56, wherein the adhesive layer comprises a pattern of adhesive.

78. The method of claim 56, wherein the multilayer laminate further comprises a sensor incorporated into the laminate to provide information as to the state of a wound or other affected area.

79. The method of claim 56, wherein the laminate is incorporated in a medical product selected from the group consisting of bandages, dressings, gauze, tape, wound closure covers, closure strips, and pads.

80. The method of claim 56, wherein the interior layer is in the form of an infraction layer.

81. The method of claim 56, wherein the interior layer includes a region of ink conduits for facilitating fluid flow through the interior layer.

82. The method of claim 81, wherein the ink conduits include a pattern defining a plurality of continuous flow channels.

83. The method of claim 81, wherein the ink conduits include a pattern defining a plurality of discontinuous flow channels.

84. A method for selectively adhering a multilayer laminate to a substrate and wound bed utilizing a vacuum assisted closure therapy;

the method comprising the steps of;

providing a multilayer laminate comprising (i) an interior layer defining a plurality of fluid passageway conduits or apertures extending through the interior layer, the interior layer exhibiting a controllable flow profile across the thickness of the interior layer, the interior layer defining a bottom surface and an oppositely directed top surface;

(ii) an adhesive layer disposed along the bottom surface of the interior layer;

(iii) a carrier layer disposed on the top surface of the interior layer; and

(iv) a release liner in contact with the adhesive layer;

placing a piece of thick material that is sized and configured to cover the wound bed, over the wound bed;

peeling off the release liner from the adhesive layer of the multilayer laminate;

applying the multilayer laminate over the wound bed;

forming a hole in the multilayer laminate;

applying a pad adapted for vacuum connection over the hole in the multilayer laminate; and

connecting a vacuum source to the pad through the hole in the multilayer laminate.

85. The method of claim 84, wherein the multilayer laminate also comprises (v) an outer cover layer disposed adjacent the carrier layer.

86. The method of claim 84, wherein the pad includes associated tubing for connection to the vacuum source.

87. The method of claim 85, wherein the pad is in contact with the outer cover layer.

88. The method of claim 84, further comprising:

selectively releasing the multilayer laminate from the substrate and wound bed.

89. The method of claim 88, wherein the selective releasing is performed by treating the multilayer laminate with an adhesive deactivating agent.

90. The method of claim 84, further comprising:

selectively releasing the multilayer laminate from the substrate and the wound bed by removing the pad and the multilayer laminate.

91. The method of claim 90, wherein the selective releasing is performed by treating the multilayer laminate with an adhesive deactivating agent.

92. The method of claim 84, wherein the adhesive of the laminate has a tackiness that decreases after an adhesive deactivating agent is applied.

93. The method of claim 84, wherein the conduits defined in the interior layer of the laminate have diameters that range from about 0.5 mils to about 2000 mils.

94. The method of claim 84, wherein the conduits have diameters that range from about 1 mil to about 400 mils.

95. The method of claim 84, wherein the conduits have diameters that range from about 10 mils to about 300 mils.

96. The method of claim 84, wherein the interior layer of the laminate includes a plurality of apertures, perforations, slits, pores or combinations thereof that enable controlled passage of one or more agents from one face of the layer through another face of the layer.

97. The method of claim 89, wherein the adhesive deactivating agent is selected from the group consisting of silicones, perfluoroalkyl derivatives, low molecular weight oils, aqueous compositions, alkyl esters, limonene derivatives, paraffin solvents, hydrocarbon solvents, alkyl ethers, aromatic esters, surfactants, and combinations thereof.

98. The method of claim 84, wherein the number of conduits or apertures in the interior layer of the laminate range from about 5 to about 500 per square inch of layer.

99. The method of claim 84, wherein the number of conduits or apertures in the interior layer of the laminate range from about 10 to about 250 per square inch of layer.

100. The method of claim 89, wherein the adhesive deactivating agent includes a medicant-like anesthetic, analgesic, cooling/heating agent or combination thereof.

101. The method of claim 89, wherein the adhesive deactivating agent is applied via a secondary carrier device.

102. The method of claim 89, wherein the adhesive deactivating agent is applied via a skin barrier-like application.

103. The method of claim 89, wherein the adhesive deactivating agent is applied via an individually sterile packed dispenser or spray.

104. The method of claim 89, wherein the adhesive deactivating agent is applied via an impregnated gauze/foam carrier.

105. The method of claim 89, wherein the adhesive deactivating agent is applied via an encapsulated release on demand medium to measure out needed amounts.

106. The method of claim 84, wherein the adhesive layer includes a pressure sensitive adhesive.

107. The method of claim 106, wherein the pressure sensitive adhesive is non-pervious to fluid flow.

108. The method of claim 106, wherein the pressure sensitive adhesive is pervious to fluid flow.

109. The method of claim 84, wherein the adhesive layer includes channels incorporated in the adhesive layer of the multilayer laminate which allows for rapid ingress of the adhesive deactivating agent.

110. The method of claim 89, wherein the adhesive deactivating agent includes a component for coating hair to eliminate hair pull induced pain during pulling off of the laminate.

111. The method of claim 84, wherein the adhesive layer comprises a pattern of adhesive.

112. The method of claim 84, wherein the multilayer laminate further comprises a sensor incorporated into the laminate to provide information as to the state of a wound or other affected area.

113. The method of claim 84, wherein the laminate is incorporated in a medical product selected from the group consisting of bandages, dressings, gauze, tape, wound closure covers, closure strips, and pads.

114. The method of claim 84, wherein the interior layer is in the form of an infraction layer.

115. The method of claim 84, wherein the interior layer includes a region of ink conduits for facilitating fluid flow through the interior layer.

116. The method of claim 115, wherein the ink conduits include a pattern defining a plurality of continuous flow channels.

117. The method of claim 115, wherein the ink conduits include a pattern defining a plurality of discontinuous flow channels.

118. A kit for use in wound care applications, comprising;

a multilayer laminate;

an adhesive to apply the laminate to a surface;

a vacuum port for use with the laminate; and

an adhesive deactivating agent for removing the adhesively applied laminate from the surface.

119. The kit of claim 118, wherein the adhesive of the laminate has a tackiness that decreases after the adhesive deactivating agent is applied.

120. The kit of claim 118, wherein the multilayer laminate includes an interior layer defining a plurality of fluid passageway conduits or apertures extending through the interior layer, the conduits defined in the interior layer having diameters that range from about 0.5 mils to about 2000 mils.

121. The kit of claim 120, wherein the conduits have diameters that range from about 1 mil to about 400 mils

122. The kit of claim 120, wherein the conduits have diameters that range from about 10 mils to about 300 mils.

123. The kit of claim 120, wherein the interior layer includes a plurality of apertures, perforations, slits, pores, or combinations thereof that enable controlled passage of one or more agents from one face of the layer through another face of the layer.

124. The kit of claim 118, wherein the adhesive deactivating agent is selected from the group consisting of silicones, perfluoroalkyl derivatives, low molecular weight oils, aqueous compositions, alkyl esters, limonene derivatives, paraffin solvents, hydrocarbon solvents, alkyl ethers, aromatic esters, surfactants, and combinations thereof.

125. The kit of claim 120, wherein the number of conduits or apertures range from about 5 to about 500 per square inch of layer.

126. The kit of claim 120, wherein the number of conduits or apertures range from about 10 to about 250 per square inch of layer.

127. The kit of claim 120, wherein the adhesive deactivating agent is a medicant-like anesthetic, analgesics, cooling/heating agent or combination thereof.

128. The kit of claim 118, wherein the adhesive deactivating agent is applied via a secondary carrier device.

129. The kit of claim 118, wherein the adhesive deactivating agent is applied via a skin barrier-like application.

130. The kit of claim 118, wherein the adhesive deactivating agent is applied via an individually sterile packed dispenser or spray.

131. The kit of claim 118, wherein the adhesive deactivating agent is applied via an impregnated gauze/foam carrier.

132. The kit of claim 118, wherein the adhesive deactivating agent is applied via an encapsulated release on demand medium to measure out needed amounts.

133. The kit of claim 118, wherein the adhesive layer includes a pressure sensitive adhesive.

134. The kit of claim 133, wherein the pressure sensitive adhesive is non-pervious to fluid flow.

135. The kit of claim 133, wherein the pressure sensitive adhesive is pervious to fluid flow.

136. The kit of claim 118, wherein the multilayer laminate includes an adhesive layer and the adhesive layer includes channels incorporated in the adhesive layer of the multilayer laminate which allows for rapid ingress of an adhesive deactivating agent.

137. The kit of claim 118, wherein the adhesive deactivating agent includes a component for coating hair to eliminate hair pull induced pain during pulling off of the laminate.

138. The kit of claim 118, wherein the adhesive is in the form of a pattern of adhesive.

139. The kit of claim 118, wherein the multilayer laminate comprises a sensor incorporated into the laminate to provide information as to the state of a wound or other affected area.

140. The kit of claim 118, wherein the laminate is incorporated in a medical product selected from the group consisting of bandages, dressings, gauze, tape, wound closure covers, closure strips, and pads.

141. The kit of claim 118, wherein the multilayer laminate includes an infraction layer.

142. The kit of claim 141, wherein the infraction layer includes a region of ink conduits for facilitating fluid flow through the interior layer.

143. The kit of claim 142, wherein the ink conduits include a pattern defining a plurality of continuous flow channels.

144. The kit of claim 142, wherein the ink conduits include a pattern defining a plurality of discontinuous flow channels.

145. A multilayer laminate adherable to a substrate and selectively releasable therefrom, the laminate comprising:

a film layer;

an adhesive layer; and

a controlled infraction layer, the infraction layer defining a face for contacting a substrate for adherence thereto,

wherein the infraction layer selectively exhibits at least one of (i) a disrupting characteristic and (ii) dissolving upon exposure to an adhesive deactivating agent.

146. The multilayer laminate of claim 145, wherein after adhering the adhesive layer to a substrate and prior to exposure to the adhesive deactivating agent, the infraction layer does not compromise the adhesion between the adhesive and the substrate.

147. The multilayer laminate of claim 145, wherein the infraction layer is delivered or applied in the form of a spray or wet wipe.

148. The multilayer laminate of claim 145, wherein the infraction layer comprises at least one agent selected from the group consisting of medicants, pain relief agents, and anti-allergy agents.

149. The multilayer laminate of claim 145, wherein the infraction layer includes provisions for interfacing with wireless information systems.

150. The multilayer laminate of claim 145, wherein the infraction layer exhibits a switchable functionality.

151. The multilayer laminate of claim 150 wherein the switchable functionality is such that a physical property of the infraction layer changes between at least two states as a result of a change in external stimuli.

152. The multilayer laminate of claim 145, wherein the infraction layer includes a region of ink conduits for facilitating fluid flow through the interior layer.

153. The multilayer laminate of claim 152, wherein the ink conduits include a pattern defining a plurality of continuous flow channels.

154. The multilayer laminate of claim 152, wherein the ink conduits include a pattern defining a plurality of discontinuous flow channels.

155. An assembly for depositing printed ink conduits on a target layer, the assembly comprising:

a low surface energy layer defining an exposed face; and

a printed ink conduit pattern disposed on the low surface energy layer, the pattern having characteristics for controlling fluid flow properties therethrough.

156. The assembly of claim 155, wherein the low surface energy layer includes a liner.

157. The assembly of claim 156, wherein the low surface energy layer includes a release coating disposed on the liner.

158. The assembly of claim 155, wherein the release coating includes a silicone release material.

159. The assembly of claim 155, wherein the pattern includes a plurality of continuous traces formed from the printed ink.

160. The assembly of claim 155, wherein the pattern includes a plurality of discontinuous traces formed from the printed ink.

161. The assembly of claim 155, wherein the target layer is an adhesive layer.

162. The assembly of claim 161, wherein the adhesive layer includes a pressure sensitive adhesive.