Method and Device for Early Signal Attenuation Detection Using Blood Glucose Measurements

• US 20120123691A1
• Filed: 01/23/2012
• Published: 05/17/2012
• Est. Priority Date: 01/29/2009
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Doniger, Kenneth J., Budiman, Erwin Satrya, Hayter, Gary
• Granted Patent: US 8,473,220 B2
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• CPC Class Codes: G16B 40/10 Signal processing, e.g. from mass spectrometry [MS] or from PCR
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis.

Claims

1. A method, comprising:

receiving one or more analyte sensor data;

receiving a reference measurement value associated with an analyte level;

determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value;

performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation; and

generating an output value based on the probability analysis.

2. The method of claim 1 wherein performing a probability analysis includes determining a sensor signal attenuation profile based on the prior analyte sensor data.

3. The method of claim 2 wherein the sensor signal attenuation profile includes a value determined at least in part by a sensor calibration schedule.

4. The method of claim 1 wherein the prior analyte sensor data includes data associated with monitored analyte level over a predetermined time period.

5. The method of claim 1 wherein performing a probability analysis includes determining the presence or the absence of signal attenuation based at least in part on the sensitivity parameter.

6. The method of claim 5 wherein the determining includes retrieving one or more parameters associated with signal attenuation associated with the sensitivity parameter.

7. The method of claim 1 including comparing the output value to a predetermined threshold level.

8. The method of claim 7 including determining the presence of signal attenuation condition for the analyte sensor based on the comparison.

9. The method of claim 7 wherein the predetermined threshold level is adjustable.

10. The method of claim 1 wherein performing the probability analysis includes applying a predetermined probability function to the sensitivity parameter.

11. The method of claim 1 including calibrating the received one or more analyte sensor data based at least in part on the determined sensitivity parameter.

12. The method of claim 11 including displaying the calibrated one or more analyte sensor data.

13. An apparatus, comprising:

a data communication interface;

one or more processors operatively coupled to the data communication interface; and

a memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to receive one or more analyte sensor data, receive a reference measurement value associated with an analyte level, determine a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, perform a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generate an output value based on the probability analysis.

14. The apparatus of claim 13 wherein the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to determine a sensor signal attenuation profile based on the prior analyte sensor data.

15. The apparatus of claim 14 wherein the sensor signal attenuation profile includes a value determined at least in part by a sensor calibration schedule.

16. The apparatus of claim 13 wherein the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to determine the presence or the absence of signal attenuation based at least in part on the sensitivity parameter.

17. The apparatus of claim 16 wherein the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to retrieve one or more parameters associated with signal attenuation associated with the sensitivity parameter.

18. The apparatus of claim 17 wherein the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to compare the output value to a predetermined threshold level.

19. The apparatus of claim 18 wherein the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to determine the presence of signal attenuation condition for the analyte sensor based on the comparison.

20. The apparatus of claim 18 wherein the predetermined threshold level is adjustable.