ANTI-IL-6 ANTIBODIES FOR THE TREATMENT OF ANEMIA
First Claim
Patent Images
1. A method of treating or preventing anemia comprising administration of a composition comprising an effective amount of an IL-6 antagonist.
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Accused Products
Abstract
The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat anemia (e.g., anemia associated with chemotherapy) including persons on a treatment regimen with a drug or chemotherapy and/or radiation for cancer (e.g., head and neck cancer) that is associated with increased risk of anemia.
53 Citations
156 Claims
- 1. A method of treating or preventing anemia comprising administration of a composition comprising an effective amount of an IL-6 antagonist.
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153. A method of identifying cancers that are potentially resistant to the effects of a chemotherapeutic or radiation by assaying for IL-6 using an antibody according to the invention in order to detect whether elevated IL-6 levels are present at the site of the treated cancer.
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154. A method for the reduction of anemia in subjects with head and heck cancer receiving concomitant chemotherapy and radiotherapy comprising administering an effective amount of a humanized monoclonal antibody that selectively binds IL-6.
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155. A method for the treating anemia in a subject with lung cancer receiving chemotherapy comprising administering an effective amount of a humanized monoclonal antibody that selectively binds IL-6, wherein said antibody is Ab1.
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Specification