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GENERATION OF UNIFORM FRAGMENTS OF NUCLEIC ACIDS USING PATTERNED SUBSTRATES

  • US 20120129704A1
  • Filed: 04/02/2010
  • Published: 05/24/2012
  • Est. Priority Date: 04/03/2009
  • Status: Active Grant
First Claim
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1. A method of generating nucleic acid fragments of substantially uniform length from one or more sample nucleic acids, comprising linearly stretching the one or more nucleic acids over a substrate comprising a plurality of cleavage regions separated by relatively consistent distances, and cleaving the one or more linearly stretched sample nucleic acids at the cleavage regions.

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