System, Method and Computer Simulation Environment For In Silico Trials in Pre-Diabetes and Type 2 Diabetes
First Claim
1. An electronic system that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, comprising:
- a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, includingan electronic module that models endogenous glucose production (EGP(t)),an electronic module that models meal glucose rate of appearance (Ra(t)),an electronic module that models glucose utilization (U(t)),an electronic module that models renal excretion of glucose (E(t));
a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, includingan electronic module that models insulin secretion (S(t));
an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters with values within a range of values derived from in vivo T2DM or prediabetic subjects; and
a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose-insulin metabolic system of a virtual subject by inputting said plurality of metabolic parameter values including said at least one varied metabolic parameter value into said glucose concentration and insulin concentration subsystems.
2 Assignments
0 Petitions
Accused Products
Abstract
An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.
-
Citations
32 Claims
-
1. An electronic system that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, comprising:
-
a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), an electronic module that models meal glucose rate of appearance (Ra(t)), an electronic module that models glucose utilization (U(t)), an electronic module that models renal excretion of glucose (E(t)); a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)); an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters with values within a range of values derived from in vivo T2DM or prediabetic subjects; and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose-insulin metabolic system of a virtual subject by inputting said plurality of metabolic parameter values including said at least one varied metabolic parameter value into said glucose concentration and insulin concentration subsystems. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A computer-executable program product embodied as computer executable code in a computer-readable storage medium, wherein said computer-executable program product simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, said computer-executable code comprising:
-
subsystem code that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic code module that models endogenous glucose production (EGP(t)), an electronic code module that models meal glucose rate of appearance (Ra(t)), an electronic code module that models glucose utilization (U(t)), an electronic code module that models renal excretion of glucose (E(t)); subsystem code that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic code module that models insulin secretion (S(t)); an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters with values within a range of values derived from in vivo T2DM or prediabetic subjects; and computer-executable code that calculates an effect of variation of at least one metabolic parameter value on the glucose-insulin metabolic system of a virtual subject by inputting said plurality of metabolic parameter values including said at least one varied metabolic parameter value into said glucose concentration and insulin concentration subsystems. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
-
Specification