SINGLE NUCLEOTIDE POLYMORPHISMS (SNP) AND ASSOCIATION WITH RESISTANCE TO IMMUNE TOLERANCE INDUCTION
First Claim
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1. A method for screening for susceptibility to immune tolerance development, comprising screening for at least one SNP.
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Abstract
This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually. This application also discloses methods for detecting variants. In addition the application addresses the use or avoidance of non steroidal anti inflammatory drugs in therapy.
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Citations
28 Claims
- 1. A method for screening for susceptibility to immune tolerance development, comprising screening for at least one SNP.
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11. A method of screening for susceptibility of a host to immune tolerance development, said method comprising:
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a. obtaining a sample from said host comprising nucleic acid; b. isolating nucleic acid from said sample; c. assaying said sample for the presence or absence of at least one SNP, wherein the presence or absence of the at least one SNP is indicative of an increased susceptibility to develop immune tolerance. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of administering at least one therapeutic agent, the method comprising
a. genotyping one or more SNP(s) in the nucleic acid of a host, b. correlating the one or more SNP(s) with one or more diseases or disorders, c. using a mathematical algorithm to determine probability that said host will respond positively or negatively to administration of at least one therapeutic agent, and d. administrating or not administrating a therapeutic agent to the host based on the results of said mathematical algorithm.
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27. A method for conducting a clinical trial in which one or more antigen(s) are evaluated, said method comprising:
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a. genotyping one or more SNP(s) relating to one or more diseases or disorders; b. analyzing the genotyping results; c. determining a course of action based on the results of said genotyping, wherein said course of action comprises i. including individual in the clinical trial based on the results of said genotyping having indicated that said individuals are likely to respond to said one or more antigen(s), and/or ii. excluding individuals from participating in the clinical trial based on the results of said genotyping having indicated that said individuals are not likely to respond to said one or more antigen(s).
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28. A method for identifying an individual who has an altered risk for developing an autoimmune disease, comprising detecting a single nucleotide polymorphism (SNP) in SEQ ID NO:
- 1 in said individual'"'"'s nucleic acids, wherein the presence of the SNP is correlated with an altered risk for autoimmune disease.
Specification