Sensor Comprising Resrufin Levulinate Having Sulfite Ion Selectivity and Method for Monitoring Sulfite Ion Using the Same

• US 20120135532A1
• Filed: 10/26/2011
• Published: 05/31/2012
• Est. Priority Date: 11/30/2010
• Status: Abandoned Application

• Current Assignee: Industry-University Cooperation Foundation Hanyang University
• Original Assignee: Industry-University Cooperation Foundation Hanyang University
• Inventors: CHANG, Suk-Kyu, CHOI, Myung Gil, EOR, Suyoung, HWANG, Jiyoung
• Application Number:
  US13/282,214
• Publication Number:
  US 20120135532A1
• Time in Patent Office: Days
• US Class Current: 436/119
• CPC Class Codes: C07D 265/38 [b, e]-condensed with two six-membered rings
• CPC Class Codes: Y10T 436/18 Sulfur containing

Abstract

The present invention relates to a sensor comprising a resorufin compound having sulfite ion selectivity and a method for detecting sulfite ions using the same. More specifically, the resorufin compound may have outstandingly increased fluorescence intensity by a deprotection reaction that a levulinyl group is cleaved with a sulfite ion to be used as a selective fluorescence sensor of turn-on type, and also represent a chromogenic change to detect sulfite ions by naked eye.

Claims

1. A compound represented by the following chemical formula 1:

2. The compound according to claim 1, wherein

R₁ to R₅ are hydrogen, and

X represents an oxygen atom.

3. A sensor for detecting sulfite ions comprising a compound represented by the following chemical formula 1:

4. The sensor for detecting sulfite ions according to claim 3, wherein

R₁ to R₅ are hydrogen, and

X represents an oxygen atom.

5. A composition for detecting sulfite ions comprising a compound represented by the following chemical formula 1:

6. The composition for detecting sulfite ions according to claim 5, wherein R₁ to R₅ are hydrogen, and X represents an oxygen atom.

7. A method for detecting sulfite ions comprising a step of being subjected to reaction of a compound represented by the following chemical formula 1 with a sample containing sulfite ions:

8. The method for detecting sulfite ions according to claim 7, wherein R₁ to R₅ are hydrogen, and X represents an oxygen atom.

9. The method for detecting sulfite ions according to claim 7, wherein the reaction is carried out under an aqueous solution having pH 7 to 10.

10. The method for detecting sulfite ions according to claim 9, wherein the aqueous solution is an aqueous solution of acetonitrile buffered with a HEPES buffer solution.

11. The method for detecting sulfite ions according to claim 7, wherein for detecting sulfite ions, increase of fluorescence intensity is measured.

12. The method for detecting sulfite ions according to claim 7, wherein for detecting sulfite ions, absorbance at 571 nm is measured.

13. The method for detecting sulfite ions according to claim 7, wherein for detecting sulfite ions, change of color in an aqueous solution from yellow to pink is measured.