INHIBITORS OF BRUTON'S TYROSINE KINASE
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Abstract
Disclosed herein are compounds that form covalent bonds with Bruton'"'"'s tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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Citations
40 Claims
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1-21. -21. (canceled)
- 22. A method for treating a cancer in a subject in need thereof comprising administering to the subject two or more agents, wherein the first agent is a selective, covalent inhibitor of Bruton'"'"'s tyrosine kinase (Btk) and the second agent is selected from paclitaxel, amrubicin, or azacitadine.
Specification