Pyridinyl Compounds Useful As Intermediates

• US 20120136158A1
• Filed: 02/08/2012
• Published: 05/31/2012
• Est. Priority Date: 09/26/2008
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: COOK, Brian Nicholas, DiSALVO, Darren, FANDRICK, Daniel Robert, HARCKEN, Christian, KUZMICH, Daniel, LEE, Thomas Wai-Ho, LIU, Pingrong, LORD, John, MAO, Can, NEU, Jochen, RAUDENBUSH, Brian Christopher, RAZAVI, Hossein, REEVES, Jonathan Timothy, SONG, Jinhua J., SWINAMER, Alan David, TAN, Zhulin
• Granted Patent: US 8,338,610 B2
• Time in Patent Office: Days
• US Class Current: 546/294
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.

Also disclosed are intermediates thereof, and methods of making and methods of using same.

Claims

1. :

A compound of the formula VIa

2. :

The compound according to claim 1 wherein the compound is;

3. :

The compound according to claim 2 wherein the compound is

4. :

A compound wherein the compound is