Anterior Segment Drug Delivery
First Claim
1. A non-corneal therapeutic system located outside of an optical zone of an eye capable of sustained release of one or more drugs to the eye for at least 30 days comprising:
- a first skeletal structure to attach, provide support, and maintain attachment of the therapeutic system of an anterior portion of the eye, anda second structure, at least partially disposed along a length of the first structure, to provide cushioning to and a means of delivering at least one drug to the eye on at least one of the two structures.
2 Assignments
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Accused Products
Abstract
A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.
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Citations
23 Claims
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1. A non-corneal therapeutic system located outside of an optical zone of an eye capable of sustained release of one or more drugs to the eye for at least 30 days comprising:
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a first skeletal structure to attach, provide support, and maintain attachment of the therapeutic system of an anterior portion of the eye, and a second structure, at least partially disposed along a length of the first structure, to provide cushioning to and a means of delivering at least one drug to the eye on at least one of the two structures.
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2. An ocular insert for use in an eye, the eye having upper and lower lids extendable along an anterior eye surface with an optical zone therebetween, the insert comprising:
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a first structure disposable along the anterior surface of the eye of a patient outside the optical zone; a second structure supported by the first structure, the second structure cushioning engagement between the insert and the eye so as to inhibit irritation of the eye when the first structure helps maintain the insert in contact with the eye for a plurality of days; and at least one drug supported by the first structure so as release a safe and therapeutically effective quantity of the drug to the eye for each of the plurality of days. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An ocular insert system for treating an eye, the eye having upper and lower lids extendable along an anterior eye surface with an optical zone therebetween, the system comprising:
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an insert engageable against the anterior surface of the eye under at least one of the lids; a re-configuration material or tool coupled to the insert so as to configure the insert in an insertion configuration, wherein activation of the material or tool reconfigures the insert to deployed configuration comprising an annulus disposable outside the optical zone between the anterior surface of the eye and the lids; and at least one drug supported by the annulus so as release a safe and therapeutically effective quantity of the drug to the eye for each of the plurality of days when deployed therein.
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23. A method of treating an eye, the method comprising:
placing a first skeletal structure on an anterior portion of the eye outside of an optical zone of the eye, wherein a second structure is at least partially disposed along a length of the first structure so as to provide cushioning to and to deliver at least one drug to the eye on at least one of the two structures.
Specification