Analyte Sensors Comprising Thickeners, Enzyme Stabilizers and Osmium Boronates
First Claim
1. An analyte sensor comprising:
- a working electrode;
a counter electrode; and
a sensing layer disposed on the working electrode, wherein the sensing layer comprises an analyte-responsive enzyme, a redox mediator and a thickener comprising one or more of urea, a urea derivative, urethane, a urethane derivative, a polyvinyl pyrrolidone polymer and a polyvinyl pyrrolidone polymer derivative.
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Accused Products
Abstract
Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution and/or improved sensitivity and/or reduced sensitivity variation of the sensing layer by inclusion of a thickener and/or an enzyme stabilizer in the sensing layer. Embodiments of the present disclosure also relate to transition metal complexes having at least one pyridine boronic acid ligand are also described. Aspects of the disclosure include transition metal complexes chemically bonded to a polymer, such as a sensing layer polymer. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
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Citations
52 Claims
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1. An analyte sensor comprising:
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a working electrode; a counter electrode; and a sensing layer disposed on the working electrode, wherein the sensing layer comprises an analyte-responsive enzyme, a redox mediator and a thickener comprising one or more of urea, a urea derivative, urethane, a urethane derivative, a polyvinyl pyrrolidone polymer and a polyvinyl pyrrolidone polymer derivative. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for monitoring a level of an analyte in a subject, the method comprising:
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positioning at least a portion of an analyte sensor into skin of a subject, wherein the analyte sensor comprises; a working electrode; a counter electrode; and a sensing layer disposed on the working electrode, wherein the sensing layer comprises an analyte-responsive enzyme, a redox mediator and a thickener comprising one or more of urea, a urea derivative, urethane, a urethane derivative, a polyvinyl pyrrolidone polymer and a polyvinyl pyrrolidone polymer derivative, and determining a level of an analyte over a period of time from signals generated by the analyte sensor, wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method for monitoring a level of an analyte using an analyte monitoring system, the method comprising:
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inserting at least a portion of an analyte sensor into skin of a patient, the analyte sensor comprising; a working electrode; a counter electrode; and a sensing layer disposed on the working electrode, wherein the sensing layer comprises an analyte-responsive enzyme, a redox mediator and a thickener comprising one or more of urea, a urea derivative, urethane, a urethane derivative, a polyvinyl pyrrolidone polymer and a polyvinyl pyrrolidone polymer derivative; attaching an analyte sensor control unit to the skin of the patient; coupling a plurality of conductive contacts of the analyte sensor control unit to a plurality of contact pads of the analyte sensor; collecting data, using the analyte sensor control unit, regarding a level of an analyte from signals generated by the analyte sensor; and transmitting the collected data from the analyte sensor control unit to a receiver unit. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of fabricating an electrode for use in an analyte sensor, the method comprising:
contacting an electrode with a sensing layer, wherein the sensing layer comprises an analyte-responsive enzyme, a redox mediator and a thickener comprising one or more of urea, a urea derivative, urethane, a urethane derivative, a polyvinyl pyrrolidone polymer and a polyvinyl pyrrolidone polymer derivative. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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52-103. -103. (canceled)
Specification