LASER-SCANNING INTERSECTING PLANE TOMOGRAPHY SUCH AS FOR HIGH SPEED VOLUMETRIC OPTICAL IMAGING
First Claim
1. An imaging apparatus comprising:
- a first lens, located and configured to receive from a sample light received from different depths of the sample;
a first light redirector, located and configured to receive via the first lens and to redirect light received from the different depths of the sample to provide redirected light to a light detector capable of detecting individual measurements of light at different locations along a first direction; and
a second light redirector, located and configured to redirect light received from a light source to provide redirected light to the sample, wherein the second light redirector is in a specified spatial relationship to the first light redirector, and wherein the first and second light redirectors are configured to be adjusted during a scan of the sample so as to provide the specified spatial relationship during the scan.
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Accused Products
Abstract
Laser-Scanning Intersecting Plane Tomography (L-SIPT) can provide a non-contact imaging geometry that can allow high speed volumetric scanning, such as of non-scattering to moderately scattering tissues. The L-SIPT imaging apparatus can include a first lens, located and configured to receive from a sample light received from different depths of the sample. A first light redirector can be located and configured to receive via the first lens and to redirect light received from the different depths of the sample to provide redirected light to a light detector capable of detecting individual measurements of light at different locations along a first direction. A second light redirector can be located and configured to redirect light received from a light source to provide redirected light to the sample, wherein the second light redirector is in a specified spatial relationship to the first light redirector, and wherein the first and second light redirectors are configured to be adjusted during a scan of the sample so as to provide the specified spatial relationship during the scan.
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Citations
24 Claims
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1. An imaging apparatus comprising:
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a first lens, located and configured to receive from a sample light received from different depths of the sample; a first light redirector, located and configured to receive via the first lens and to redirect light received from the different depths of the sample to provide redirected light to a light detector capable of detecting individual measurements of light at different locations along a first direction; and a second light redirector, located and configured to redirect light received from a light source to provide redirected light to the sample, wherein the second light redirector is in a specified spatial relationship to the first light redirector, and wherein the first and second light redirectors are configured to be adjusted during a scan of the sample so as to provide the specified spatial relationship during the scan. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An imaging apparatus comprising:
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a light source, including a collimated light source configured to provide a light beam or a light sheet; a light detector capable of detecting individual measurements of light at different locations along a first direction; a first lens, located and configured to receive from a sample light received from different depths of the sample; a first light redirector, comprising a first reflector, located and configured to receive via the first lens and to redirect light received from the different depths of the sample to provide redirected light to the light detector; a second lens, located and configured to refract the light received from the different depths of the sample and redirected by the first light redirector, to provide refracted light to the light detector; a second light redirector, comprising a second reflector, located and configured to redirect light received from the light source to provide redirected light to the sample via the first lens, wherein the second light redirector is in a specified fixed spatial relationship to the first light redirector, and wherein the first and second light redirectors are adjacent facets on a rotating polygon mirror and are configured to move together during a scan of the sample so as to provide the specified fixed spatial relationship during the scan of the sample; and a processor circuit configured to include or access a processor-readable medium that includes instructions or information that configure the processor circuit to be capable of translating (1) scan data provided by redirected light detected by the light detector to (2) two-dimensional (2D) or three-dimensional (3D) image data at appropriate image pixel positions corresponding to locations within the sample from which the redirected light detected by the light detector is received, the translating including using information about (1) a scan angle and (2) a lens characteristic of the first lens. - View Dependent Claims (14)
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15. A method comprising:
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receiving, from a sample, light from different depths of the sample; redirecting, using a first light redirector, the light received from the sample to provide light to a light detector capable of detecting individual measurements of light at different locations along a first direction; redirecting light from a light source, using a second light redirector, to provide light to the sample, wherein the first and second light redirectors are configured in a specified spatial relationship to each other; and adjusting the first and second light redirectors during a scan of the sample so as to provide the specified spatial relationship during the scan. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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22. A method comprising:
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receiving, from a sample, light received from different depths of the sample; redirecting, using a first light redirector, the light received from the sample to provide light to a light detector capable of detecting light at different locations along a first direction; refracting light from the sample to be provided to the first light redirector; redirecting light from a light source, using a second light redirector, to provide light to the sample, wherein the first and second light redirectors are positioned in a fixed spatial relationship to each other; refracting light from the light source to be provided to the sample by sharing a lens that is also used in the refracting light from the sample to be provided to the first light redirector; scanning the sample, the scanning including; rotating a multifaceted mirror in which adjacent facets provide the first and second light redirectors that rotate together so as to provide a specified fixed spatial relationship to each other during the scan; and repeating light detection at different rotational positions of the mirror; and translating (1) scan data provided by redirected light detected by the light detector to (2) two-dimensional (2D) or three-dimensional (3D) image data at appropriate image pixel positions corresponding to locations within the sample from which the redirected light detected by the light detector is received, the translating including using information about (1) a scan angle and (2) a lens characteristic of a first lens. - View Dependent Claims (23, 24)
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Specification