METHOD FOR ESTIMATING HAEOMODYNAMIC PARAMETERS BY JOINT ESTIMATION OF THE PARAMETERS OF A GLOBAL PERFUSION MODEL
First Claim
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1. A method for estimating one or more haemodynamic perfusion parameters of an elementary volume—
- referred to as a voxel—
of an organ, said method being implemented by a processing unit of a perfusion imaging analysis system, and comprising a step for estimating one or more haemodynamic parameters from perfusion signals S(t), wherein the step for estimating the haemodynamic parameter or parameters includes a joint estimation of the parameters Θ
of a global perfusion model comprising;
a first relationship between the perfusion signal S(t) and a concentration C(t) of a contrast agent circulating in said voxel over a time t;
a second relationship between the concentration C(t) of a contrast agent, the blood flow BF, a parametric or semiparametric model Ca(t,Θ
a) of an arterial input function and a parametric or semiparametric model R(t,Θ
R) of a complementary cumulative distribution function of the transit time in the voxel, Θ
a and Θ
R being respectively the parameters of the models Ca(t,Θ
a) and R(t,Θ
R).
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Abstract
The invention relates to a method for estimating haemodynamic perfusion parameters of an elementary volume—termed a voxel—of an organ, from perfusion signals by jointly estimating the parameters of an optionally limited comprehensive perfusion model. The invention moreover relates to a processing unit of a perfusion imaging analysis system, adapted for carrying out such a method and for delivering the estimated parameters according to an appropriate format to a human-machine interface able to represent said estimated parameters for a user.
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Citations
25 Claims
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1. A method for estimating one or more haemodynamic perfusion parameters of an elementary volume—
- referred to as a voxel—
of an organ, said method being implemented by a processing unit of a perfusion imaging analysis system, and comprising a step for estimating one or more haemodynamic parameters from perfusion signals S(t), wherein the step for estimating the haemodynamic parameter or parameters includes a joint estimation of the parameters Θ
of a global perfusion model comprising;a first relationship between the perfusion signal S(t) and a concentration C(t) of a contrast agent circulating in said voxel over a time t; a second relationship between the concentration C(t) of a contrast agent, the blood flow BF, a parametric or semiparametric model Ca(t,Θ
a) of an arterial input function and a parametric or semiparametric model R(t,Θ
R) of a complementary cumulative distribution function of the transit time in the voxel, Θ
a and Θ
R being respectively the parameters of the models Ca(t,Θ
a) and R(t,Θ
R). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- referred to as a voxel—
Specification